Literature DB >> 28548311

Multivalency To Inhibit and Discriminate Hexosaminidases.

Dimitri Alvarez-Dorta1, Dustin T King2, Thibaut Legigan3, Daisuke Ide4, Isao Adachi4, David Deniaud1, Jérôme Désiré3, Atsushi Kato4, David Vocadlo2, Sébastien G Gouin1, Yves Blériot3.   

Abstract

A set of multivalent polyhydroxylated acetamidoazepanes based on ethylene glycol, glucoside, or cyclodextrin scaffolds was prepared. The compounds were assessed against plant, mammalian, and therapeutically relevant hexosaminidases. Multimerization was shown to improve the inhibitory potency with synergy, and to fine tune the selectivity profile between related hexosaminidases.
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  exo-N-acetyl-β-glucosaminidases; glycoclusters; glycosidases; iminosugars; multivalency

Mesh：

Substances：

Year:  2017        PMID： 28548311     DOI： 10.1002/chem.201701756

Source DB:  PubMed          Journal:  Chemistry        ISSN： 0947-6539            Impact factor:   5.236


  4 in total

1.  Glycosidase Inhibition by Multivalent Presentation of Heparan Sulfate Saccharides on Bottlebrush Polymers.

Authors:  Eric T Sletten; Ravi S Loka; Fei Yu; Hien M Nguyen
Journal:  Biomacromolecules       Date:  2017-09-13       Impact factor: 6.988

2.  Multivalency Increases the Binding Strength of RGD Peptidomimetic-Paclitaxel Conjugates to Integrin αV β3.

Authors:  André Raposo Moreira Dias; Arianna Pina; Alberto Dal Corso; Daniela Arosio; Laura Belvisi; Luca Pignataro; Michele Caruso; Cesare Gennari
Journal:  Chemistry       Date:  2017-09-06       Impact factor: 5.236

Review 3.  GCase Enhancers: A Potential Therapeutic Option for Gaucher Disease and Other Neurological Disorders.

Authors:  Macarena Martínez-Bailén; Francesca Clemente; Camilla Matassini; Francesca Cardona
Journal:  Pharmaceuticals (Basel)       Date:  2022-07-02

4.  3,4,5-Trihydroxypiperidine Based Multivalent Glucocerebrosidase (GCase) Enhancers.

Authors:  Costanza Vanni; Francesca Clemente; Paolo Paoli; Amelia Morrone; Camilla Matassini; Andrea Goti; Francesca Cardona
Journal:  Chembiochem       Date:  2022-04-07       Impact factor: 3.461
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.