Literature DB >> 28548207

Pharmacometric Modeling of Naloxegol Efficacy and Safety: Impact on Dose and Label.

N Al-Huniti1, D Zhou1, H Xu1, S Aksenov1, K H Bui1, R Fox1, G Helmlinger1, D Stanski1.   

Abstract

Naloxegol is a peripherally acting μ-opioid receptor antagonist that was developed for the treatment of opioid-induced constipation. Modeling and simulation of naloxegol efficacy and tolerability informed selection of doses for phase III studies and provided comprehensive dosage recommendations for the naloxegol US package insert.
© 2017 ASCPT.

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Year:  2017        PMID： 28548207     DOI： 10.1002/cpt.719

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  4 in total

1.  Population pharmacokinetic analysis of danvatirsen supporting flat dosing switch.

Authors:  Hongmei Xu; Xiao Tong; Ganesh Mugundu; Martin L Scott; Carl Cook; Cecilia Arfvidsson; Elizabeth Pease; Diansong Zhou; Paul Lyne; Nidal Al-Huniti
Journal:  J Pharmacokinet Pharmacodyn       Date:  2019-01-19       Impact factor: 2.745

2.  Simplified Aztreonam Dosing in Patients with End-Stage Renal Disease: Results of a Monte Carlo Simulation.

Authors:  Alan E Gross; Hongmei Xu; Diansong Zhou; Nidal Al-Huniti
Journal:  Antimicrob Agents Chemother       Date:  2018-10-24       Impact factor: 5.191

3.  The combination of Cassia obtusifolia L. and Foeniculum vulgare M. exhibits a laxative effect on loperamide-induced constipation of rats.

Authors:  Seung Hee Jang; Dong Kwon Yang
Journal:  PLoS One       Date:  2018-04-05       Impact factor: 3.240

4.  Evaluation of the Drug-Drug Interaction Potential of Acalabrutinib and Its Active Metabolite, ACP-5862, Using a Physiologically-Based Pharmacokinetic Modeling Approach.

Authors:  Diansong Zhou; Terry Podoll; Yan Xu; Ganesh Moorthy; Karthick Vishwanathan; Joseph Ware; J Greg Slatter; Nidal Al-Huniti
Journal:  CPT Pharmacometrics Syst Pharmacol       Date:  2019-05-12
  4 in total

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