Literature DB >> 28548143

Rapid and efficient tetrazine-induced drug release from highly stable benzonorbornadiene derivatives.

Minghao Xu1, Julian Tu, Raphael M Franzini.   

Abstract

A novel class of bioorthogonal release reactions based on benzonorbornadiene derivatives was developed. These carrier molecules are highly stable at physiological conditions, but react rapidly with 1,2,4,5-tetrazines, and near-quantitatively release cargo molecules such as drugs and optical reporters.

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Year:  2017        PMID: 28548143     DOI: 10.1039/c7cc03477f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  9 in total

1.  Bioorthogonal Click and Release: A General, Rapid, Chemically Revertible Bioconjugation Strategy Employing Enamine N-oxides.

Authors:  Dahye Kang; Sanghyeon Lee; Justin Kim
Journal:  Chem       Date:  2022-06-15       Impact factor: 25.832

2.  Stable, Reactive, and Orthogonal Tetrazines: Dispersion Forces Promote the Cycloaddition with Isonitriles.

Authors:  Julian Tu; Dennis Svatunek; Saba Parvez; Albert C Liu; Brian J Levandowski; Hannah J Eckvahl; Randall T Peterson; Kendall N Houk; Raphael M Franzini
Journal:  Angew Chem Int Ed Engl       Date:  2019-06-06       Impact factor: 16.823

Review 3.  The Future of Bioorthogonal Chemistry.

Authors:  Neal K Devaraj
Journal:  ACS Cent Sci       Date:  2018-07-23       Impact factor: 14.553

4.  Concise Synthesis of Functionalized Cyclobutene Analogues for Bioorthogonal Tetrazine Ligation.

Authors:  Jiayu Sun; Jie Li; Hongbao Sun; Chunling Li; Haoxing Wu
Journal:  Molecules       Date:  2021-01-08       Impact factor: 4.411

Review 5.  Activation and Delivery of Tetrazine-Responsive Bioorthogonal Prodrugs.

Authors:  Yayue Wang; Chang Zhang; Haoxing Wu; Ping Feng
Journal:  Molecules       Date:  2020-11-30       Impact factor: 4.411

6.  Tetrazine-Induced Bioorthogonal Activation of Vitamin E-Modified siRNA for Gene Silencing.

Authors:  Xueli Zhang; Amu Gubu; Jianfei Xu; Ning Yan; Wenbo Su; Di Feng; Qian Wang; Xinjing Tang
Journal:  Molecules       Date:  2022-07-08       Impact factor: 4.927

7.  Targeted Molecular Construct for Bioorthogonal Theranostics of PD-L1-Expressing Cancer Cells.

Authors:  Shiao Y Chow; Asier Unciti-Broceta
Journal:  JACS Au       Date:  2022-07-01

Review 8.  Bioorthogonal Ligations and Cleavages in Chemical Biology.

Authors:  Youshan Li; Hua Fu
Journal:  ChemistryOpen       Date:  2020-08-14       Impact factor: 2.911

9.  Isonitrile-responsive and bioorthogonally removable tetrazine protecting groups.

Authors:  Julian Tu; Dennis Svatunek; Saba Parvez; Hannah J Eckvahl; Minghao Xu; Randall T Peterson; K N Houk; Raphael M Franzini
Journal:  Chem Sci       Date:  2019-11-05       Impact factor: 9.825

  9 in total

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