Andreea Ciudin1, Ana Espinosa2, Olga Simó-Servat1, Agustín Ruiz2, Montserrat Alegret2, Cristina Hernández1, Mercè Boada2, Rafael Simó3. 1. Institut de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona (VHIR-UAB), Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Spain. 2. Fundació ACE, Barcelona Alzheimer Treatment & Research Center, Barcelona, Spain. 3. Institut de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona (VHIR-UAB), Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Spain. Electronic address: rafael.simo@vhir.org.
Abstract
AIMS: To explore whether type 2 diabetes (T2D) is a risk factor for dementia conversion in patients with mild cognitive impairment (MCI). METHODS: A longitudinal nested case-control study in which 101 T2D patients and 101 non-diabetic patients with MCI matched by age and gender were included. RESULTS: The dementia conversion rate was 57.4% in T2D patients vs. 42.6% in non-diabetic subjects (p=0.02). T2D and APOE ε4 allele were independent risk factors for developing dementia. CONCLUSION: T2D is an independent risk factor for dementia conversion in MCI patients. This finding has significant clinical implications.
AIMS: To explore whether type 2 diabetes (T2D) is a risk factor for dementia conversion in patients with mild cognitive impairment (MCI). METHODS: A longitudinal nested case-control study in which 101 T2D patients and 101 non-diabeticpatients with MCI matched by age and gender were included. RESULTS: The dementia conversion rate was 57.4% in T2D patients vs. 42.6% in non-diabetic subjects (p=0.02). T2D and APOE ε4 allele were independent risk factors for developing dementia. CONCLUSION: T2D is an independent risk factor for dementia conversion in MCI patients. This finding has significant clinical implications.
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