Tabitha A Iseger1, Frank Padberg2, J Leon Kenemans3, Richard Gevirtz4, Martijn Arns5. 1. Dept. of Experimental Psychology, Utrecht University, Utrecht, The Netherlands; Research Institute Brainclinics, Nijmegen, The Netherlands. Electronic address: tabitha@brainclinics.com. 2. Dept. Psychiatry and Psychotherapy, Ludwig-Maximilian University Munich, Germany. 3. Dept. of Experimental Psychology, Utrecht University, Utrecht, The Netherlands. 4. Alliant International University, San Diego, CA, USA. 5. Dept. of Experimental Psychology, Utrecht University, Utrecht, The Netherlands; Research Institute Brainclinics, Nijmegen, The Netherlands; neuroCare Group, Munich, Germany.
Abstract
BACKGROUND: Given that many studies suggest a role of DLPFC-sgACC connectivity in depression and prior research demonstrating that neuromodulation of either of these nodes modulates parasympathetic activity and results in a heart rate deceleration, a new method is proposed to individualize localization of the DLPFC. This can, among others, be useful for rTMS treatment of depression. METHODS: Ten healthy subjects received three trains of 10Hz rTMS randomly over 7 target regions (10-20 system). RESULTS: Overall, F3 and F4 expressed the largest heart rate deceleration, in line with studies suggesting these are the best 10-20 sites to target the DLPFC. On the individual level, 20-40% subjects expressed the largest heart rate deceleration at FC3 or FC4, indicating individual differences as to the 'optimal site for stimulation'. CONCLUSIONS: These results show that the NCG-TMS method is valid to localize the entry into the DLPFC-sgACC network.
BACKGROUND: Given that many studies suggest a role of DLPFC-sgACC connectivity in depression and prior research demonstrating that neuromodulation of either of these nodes modulates parasympathetic activity and results in a heart rate deceleration, a new method is proposed to individualize localization of the DLPFC. This can, among others, be useful for rTMS treatment of depression. METHODS: Ten healthy subjects received three trains of 10Hz rTMS randomly over 7 target regions (10-20 system). RESULTS: Overall, F3 and F4 expressed the largest heart rate deceleration, in line with studies suggesting these are the best 10-20 sites to target the DLPFC. On the individual level, 20-40% subjects expressed the largest heart rate deceleration at FC3 or FC4, indicating individual differences as to the 'optimal site for stimulation'. CONCLUSIONS: These results show that the NCG-TMS method is valid to localize the entry into the DLPFC-sgACC network.
Authors: Alisson P Trevizol; Jonathan Downar; Fidel Vila-Rodriguez; Kevin E Thorpe; Zafiris J Daskalakis; Daniel M Blumberger Journal: EClinicalMedicine Date: 2020-04-30
Authors: Abrahão Fontes Baptista; Adriana Baltar; Alexandre Hideki Okano; Alexandre Moreira; Ana Carolina Pinheiro Campos; Ana Mércia Fernandes; André Russowsky Brunoni; Bashar W Badran; Clarice Tanaka; Daniel Ciampi de Andrade; Daniel Gomes da Silva Machado; Edgard Morya; Eduardo Trujillo; Jaiti K Swami; Joan A Camprodon; Katia Monte-Silva; Katia Nunes Sá; Isadora Nunes; Juliana Barbosa Goulardins; Marom Bikson; Pedro Sudbrack-Oliveira; Priscila de Carvalho; Rafael Jardim Duarte-Moreira; Rosana Lima Pagano; Samuel Katsuyuki Shinjo; Yossi Zana Journal: Front Neurol Date: 2020-11-25 Impact factor: 4.003