Yanzhi Bi1, Yajuan Zhang1, Yangding Li2, Dahua Yu3, Kai Yuan4, Jie Tian5. 1. School of Life Science and Technology, Xidian University, Xi'an, PR China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, PR China. 2. Guangxi Key Laboratory of Multi-source Information Mining and Security, Guangxi Normal University, Guilin, PR China. 3. Information Processing Laboratory, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, PR China. 4. School of Life Science and Technology, Xidian University, Xi'an, PR China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, PR China; Information Processing Laboratory, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, PR China. Electronic address: kyuan@xidian.edu.cn. 5. School of Life Science and Technology, Xidian University, Xi'an, PR China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, PR China; Institute of Automation, Chinese Academy of Sciences, Beijing, PR China. Electronic address: tian@ieee.org.
Abstract
BACKGROUND: The strong craving to smoke is a core factor of smoking abstinence that precipitates relapse. Insula plays critical roles in maintaining nicotine dependence, especially in the interoceptive awareness of craving. Despite evidence indicating a link between insula and abstinence-induced craving, less is known about the neural basis of abstinence-induced craving from the circuit level of insula. METHODS: The present study examined the effects of 12h of abstinence from smoking on the resting state functional connectivity (RSFC) of anterior (AI) and posterior insula in young smokers using a within-subject design. Thirty-three young male smokers underwent functional magnetic resonance imaging scanning on two separate sessions: (1) smoking satiety and (2) abstinence (after ≥12h of smoking deprivation), in counterbalanced order. Multiple regression analysis was applied to investigate the possible relationships between the RSFC changes of insula (abstinence minus satiety) and the abstinence-induced craving changes. RESULTS: Smoking abstinence state (versus satiety) was associated with increased RSFC between right AI and right medial orbitofrontal cortex (OFC), ventromedial prefrontal cortex as well as anterior cingulate cortex. The abstinence-induced RSFC changes between right AI and right lateral OFC was significantly correlated with the craving changes. CONCLUSIONS: These findings improve the understanding of the effects of short-term smoking abstinence on insula circuit connectivity and may contribute new insights into the neural basis of abstinence-induced craving to smoke.
BACKGROUND: The strong craving to smoke is a core factor of smoking abstinence that precipitates relapse. Insula plays critical roles in maintaining nicotine dependence, especially in the interoceptive awareness of craving. Despite evidence indicating a link between insula and abstinence-induced craving, less is known about the neural basis of abstinence-induced craving from the circuit level of insula. METHODS: The present study examined the effects of 12h of abstinence from smoking on the resting state functional connectivity (RSFC) of anterior (AI) and posterior insula in young smokers using a within-subject design. Thirty-three young male smokers underwent functional magnetic resonance imaging scanning on two separate sessions: (1) smoking satiety and (2) abstinence (after ≥12h of smoking deprivation), in counterbalanced order. Multiple regression analysis was applied to investigate the possible relationships between the RSFC changes of insula (abstinence minus satiety) and the abstinence-induced craving changes. RESULTS: Smoking abstinence state (versus satiety) was associated with increased RSFC between right AI and right medial orbitofrontal cortex (OFC), ventromedial prefrontal cortex as well as anterior cingulate cortex. The abstinence-induced RSFC changes between right AI and right lateral OFC was significantly correlated with the craving changes. CONCLUSIONS: These findings improve the understanding of the effects of short-term smoking abstinence on insula circuit connectivity and may contribute new insights into the neural basis of abstinence-induced craving to smoke.
Authors: Sarah W Yip; Sarah D Lichenstein; Kathleen Garrison; Christopher L Averill; Humsini Viswanath; Ramiro Salas; Chadi G Abdallah Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Date: 2021-02-19
Authors: Claire E Wilcox; Christopher C Abbott; Vince D Calhoun Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2018-06-25 Impact factor: 5.067