Matthew McCarthy1,2,3, Charlotte L Edwardson1,2, Melanie J Davies1,2,4, Joseph Henson1,2, Alex Rowlands1,2, James A King2, Danielle H Bodicoat1,2,5, Kamlesh Khunti1,5,4, Thomas Yates1,2. 1. Diabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester, UK. 2. National Institute for Health Research, Leicester, Biomedical Research Centre, Leicester Diabetes Centre, Leicester, UK. 3. Department of Health Sciences, Leicester General Hospital, University of Leicester, Leicester, UK. 4. Leicester Diabetes Centre, Leicester General Hospital, University Hospitals of Leicester, Leicester, UK. 5. National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care - East Midlands, Leicester Diabetes Centre, Leicester, UK.
Abstract
AIMS: To investigate the impact of performing short bouts of seated upper body activity on postprandial blood glucose and insulin levels during prolonged sitting. METHODS: Participants undertook two 7.5-hour experimental conditions in randomized order: (1) prolonged sitting only and (2) sitting, interspersed with 5 minutes of seated arm ergometry every 30 minutes. Blood samples were obtained while fasting and throughout the postprandial period after ingestion of two standardized meals. The incremental area under the curve (iAUC) was calculated for glucose and insulin throughout each experimental condition. A paired samples t-test was used to assess the difference in iAUC data between conditions for glucose (primary outcome) and insulin (secondary outcome). RESULTS:Thirteen obese adults (7 women, 6 men; mean ± standard deviation [s.d.] age: 66 ± 6 years; body mass index 33.8 ± 3.8 kg/m2 ) completed this investigation. Compared with the prolonged sitting-only condition, the implementation of seated arm ergometry every 30 minutes significantly reduced mean blood glucose iAUC (from 7.4 mmol/L/h [95% confidence interval {CI} 5.2, 9.5] to 3.1 mmol/L/h [95% CI 1.3, 5.0]; P = .001). Significant reductions in mean insulin iAUC (from 696 mU/L/h [95% CI 359, 1032] to 554 mU/L/h [95% CI 298, 811]; P = .047) were also observed. CONCLUSION: Performing short bouts of arm ergometry during prolonged sitting attenuated postprandial glycaemia despite maintaining a seated posture. This may have clinical significance for those with weight-bearing difficulty who may struggle with postural change.
RCT Entities:
AIMS: To investigate the impact of performing short bouts of seated upper body activity on postprandial blood glucose and insulin levels during prolonged sitting. METHODS:Participants undertook two 7.5-hour experimental conditions in randomized order: (1) prolonged sitting only and (2) sitting, interspersed with 5 minutes of seated arm ergometry every 30 minutes. Blood samples were obtained while fasting and throughout the postprandial period after ingestion of two standardized meals. The incremental area under the curve (iAUC) was calculated for glucose and insulin throughout each experimental condition. A paired samples t-test was used to assess the difference in iAUC data between conditions for glucose (primary outcome) and insulin (secondary outcome). RESULTS: Thirteen obese adults (7 women, 6 men; mean ± standard deviation [s.d.] age: 66 ± 6 years; body mass index 33.8 ± 3.8 kg/m2 ) completed this investigation. Compared with the prolonged sitting-only condition, the implementation of seated arm ergometry every 30 minutes significantly reduced mean blood glucose iAUC (from 7.4 mmol/L/h [95% confidence interval {CI} 5.2, 9.5] to 3.1 mmol/L/h [95% CI 1.3, 5.0]; P = .001). Significant reductions in mean insulin iAUC (from 696 mU/L/h [95% CI 359, 1032] to 554 mU/L/h [95% CI 298, 811]; P = .047) were also observed. CONCLUSION: Performing short bouts of arm ergometry during prolonged sitting attenuated postprandial glycaemia despite maintaining a seated posture. This may have clinical significance for those with weight-bearing difficulty who may struggle with postural change.
Authors: Matthew McCarthy; Thomas Yates; David Webb; Frances Game; Laura Gray; Melanie J Davies Journal: BMJ Open Date: 2020-06-21 Impact factor: 2.692
Authors: Paul Mackie; Ishanka Weerasekara; Gary Crowfoot; Heidi Janssen; Elizabeth Holliday; David Dunstan; Coralie English Journal: PLoS One Date: 2019-06-13 Impact factor: 3.240
Authors: Natalie Tyldesley-Marshall; Sheila M Greenfield; Helen M Parretti; Kajal Gokal; Colin Greaves; Kate Jolly; Ralph Maddison; Amanda J Daley Journal: Int J Behav Med Date: 2021-11-15
Authors: Joseph Henson; Charlotte L Edwardson; Carlos A Celis-Morales; Melanie J Davies; David W Dunstan; Dale W Esliger; Jason M R Gill; Aadil Kazi; Kamlesh Khunti; James King; Matthew McCarthy; Naveed Sattar; David J Stensel; Latha Velayudhan; Francesco Zaccardi; Thomas Yates Journal: Med Sci Sports Exerc Date: 2020-06