Literature DB >> 28541488

The role of IL-12/23 in T cell-related chronic inflammation: implications of immunodeficiency and therapeutic blockade.

Anna Schurich1, Charles Raine2, Vanessa Morris2, Coziana Ciurtin2.   

Abstract

In this review we discuss the divergent role of two closely related cytokines, IL-12 and IL-23, in shaping immune responses. In light of current therapeutic developments using biologic agents to block these two pathways, a better understanding of the immunological function of these cytokines is pivotal.
© The Author 2017. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Entities:  

Keywords:  IL-12 related immunodeficiency; IL-12/23 blockade; briakinumab; psoriasis; psoriatic arthritis; ustekinumab

Mesh：

Substances：

Year:  2018        PMID： 28541488     DOI： 10.1093/rheumatology/kex186

Source DB:  PubMed          Journal:  Rheumatology (Oxford)        ISSN： 1462-0324            Impact factor:   7.580


  7 in total

1.  Exposure-response characterisation of tildrakizumab in chronic plaque psoriasis: Pooled analysis of 3 randomised controlled trials.

Authors:  Thomas Kerbusch; Hanbin Li; Russell Wada; Petra M Jauslin; Larissa Wenning
Journal:  Br J Clin Pharmacol       Date:  2020-03-25       Impact factor: 4.335

2.  Population pharmacokinetics and exposure-response modeling analyses of guselkumab in patients with psoriatic arthritis.

Authors:  Yang Chen; Xin Miao; Chyi-Hung Hsu; Yanli Zhuang; Alexa Kollmeier; Zhenhua Xu; Honghui Zhou; Amarnath Sharma
Journal:  Clin Transl Sci       Date:  2021-12-02       Impact factor: 4.689

3.  Suppression of IL-12/IL-23 p40 subunit in the skin and blood of psoriasis patients by Tofacitinib is dependent on active interferon-γ signaling in dendritic cells: Implications for the treatment of psoriasis and interferon-driven diseases.

Authors:  Nanette L A Vincken; Paco M J Welsing; Sandra C Silva-Cardoso; Cornelis P J Bekker; Ana P Lopes; Michel Olde Nordkamp; Emmerik F A Leijten; Timothy R D J Radstake; Chiara Angiolilli
Journal:  Exp Dermatol       Date:  2022-03-21       Impact factor: 4.511

Review 4.  Risk of Candida Infection and Serious Infections in Patients with Moderate-to-Severe Psoriasis Receiving Biologics: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Authors:  Yue Feng; Baosen Zhou; Zhen Wang; Guijuan Xu; Lili Wang; Tingting Zhang; Yanping Zhang
Journal:  Int J Clin Pract       Date:  2022-09-21       Impact factor: 3.149

5.  Immunodeficiency Promotes Adaptive Alterations of Host Gut Microbiome: An Observational Metagenomic Study in Mice.

Authors:  Shuyu Zheng; Tingting Zhao; Shuijuan Yuan; Lingyu Yang; Jinmei Ding; Li Cui; Mingqing Xu
Journal:  Front Microbiol       Date:  2019-11-01       Impact factor: 5.640

6.  Impact of intrarectal chromofungin treatment on dendritic cells-related markers in different immune compartments in colonic inflammatory conditions.

Authors:  Kunal Kapoor; Nour Eissa; Diane Tshikudi; Charles N Bernstein; Jean-Eric Ghia
Journal:  World J Gastroenterol       Date:  2021-12-21       Impact factor: 5.742

Review 7.  Autoimmunity in psoriatic arthritis: pathophysiological and clinical aspects

Authors:  Hakan Emmungil; Ufuk İlgen; Rafi Haner Direskeneli
Journal:  Turk J Med Sci       Date:  2021-08-30       Impact factor: 0.973
  7 in total

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