Literature DB >> 28540559

Ceramide and S1P Signaling in Embryonic Stem Cell Differentiation.

Guanghu Wang1, Stefka D Spassieva2, Erhard Bieberich3,4.   

Abstract

Bioactive sphingolipids are important regulators for stem cell survival and differentiation. Most recently, we have coined the term "morphogenetic lipids" for sphingolipids that regulate stem cells during embryonic and postnatal development. The sphingolipid ceramide and its derivative, sphingosine-1-phosphate (S1P), can act synergistically as well as antagonistically on embryonic stem (ES) cell differentiation. We show here simple as well as state-of-the-art methods to analyze sphingolipids in differentiating ES cells and discuss new protocols to use ceramide and S1P analogs for the guided differentiation of mouse ES cells toward neuronal and glial lineage.

Entities:  

Keywords:  Apoptosis; Ceramide; Neuroprogenitor; Oligodendrocyte precursor; Sphingolipid; Sphingosine-1-phosphate; Teratoma

Mesh：

Substances：

Year:  2018        PMID： 28540559      PMCID： PMC5815858          DOI： 10.1007/7651_2017_43

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  59 in total

1.  Sphingosine-1-Phosphate (S1P) Signaling in Neural Progenitors.

Authors:  Phillip Callihan; Mohammed Alqinyah; Shelley B Hooks
Journal:  Methods Mol Biol       Date:  2018

2.  Effect of harvesting methods, growth conditions and growth phase on diacylglycerol levels in cultured human adherent cells.

Authors:  P P Van Veldhoven; R M Bell
Journal:  Biochim Biophys Acta       Date:  1988-03-25

3.  Teratoma formation leads to failure of treatment for type I diabetes using embryonic stem cell-derived insulin-producing cells.

Authors:  Takahisa Fujikawa; Seh-Hoon Oh; Liya Pi; Heather M Hatch; Tom Shupe; Bryon E Petersen
Journal:  Am J Pathol       Date:  2005-06       Impact factor: 4.307

4.  Synthesis and characterization of novel ceramide analogs for induction of apoptosis in human cancer cells.

Authors:  Erhard Bieberich; Bin Hu; Jeane Silva; Sarah MacKinnon; Robert K Yu; Helen Fillmore; William C Broaddus; Raphael M Ottenbrite
Journal:  Cancer Lett       Date:  2002-07-08       Impact factor: 8.679

5.  There is more to a lipid than just being a fat: sphingolipid-guided differentiation of oligodendroglial lineage from embryonic stem cells.

Authors:  Erhard Bieberich
Journal:  Neurochem Res       Date:  2010-12-07       Impact factor: 3.996

6.  Ceramide regulates atypical PKCzeta/lambda-mediated cell polarity in primitive ectoderm cells. A novel function of sphingolipids in morphogenesis.

Authors:  Kannan Krishnamurthy; Guanghu Wang; Jeane Silva; Brian G Condie; Erhard Bieberich
Journal:  J Biol Chem       Date:  2006-11-14       Impact factor: 5.157

7.  In vivo differentiation of mouse embryonic stem cells into hepatocytes.

Authors:  Dongho Choi; Hyun-Jeong Oh; Uck-Jin Chang; Soo Kyung Koo; Jean X Jiang; Sue-Yun Hwang; Jung-Dal Lee; George C Yeoh; Hee-Sup Shin; Jin-Sung Lee; Bermseok Oh
Journal:  Cell Transplant       Date:  2002       Impact factor: 4.064

8.  Ceramide signaling in cancer and stem cells.

Authors:  Erhard Bieberich
Journal:  Future Lipidol       Date:  2008-06

9.  Sphingosine Phosphate Lyase Regulates Murine Embryonic Stem Cell Proliferation and Pluripotency through an S1P2/STAT3 Signaling Pathway.

Authors:  Gaelen S Smith; Ashok Kumar; Julie D Saba
Journal:  Biomolecules       Date:  2013-06-24

10.  Regulation of Chlamydomonas flagella and ependymal cell motile cilia by ceramide-mediated translocation of GSK3.

Authors:  Ji Na Kong; Kara Hardin; Michael Dinkins; Guanghu Wang; Qian He; Tarik Mujadzic; Gu Zhu; Jacek Bielawski; Stefka Spassieva; Erhard Bieberich
Journal:  Mol Biol Cell       Date:  2015-10-07       Impact factor: 4.138
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  9 in total

Review 1.  Sphingolipids and lipid rafts: Novel concepts and methods of analysis.

Authors:  Erhard Bieberich
Journal:  Chem Phys Lipids       Date:  2018-09-05       Impact factor: 3.329

2.  An Update on Sphingolipidomics: Is Something Still Missing? Some Considerations on the Analysis of Complex Sphingolipids and Free-Sphingoid Bases in Plasma and Red Blood Cells.

Authors:  Camillo Morano; Aida Zulueta; Anna Caretti; Gabriella Roda; Rita Paroni; Michele Dei Cas
Journal:  Metabolites       Date:  2022-05-17

Review 3.  Sphingolipids in neurodegeneration (with focus on ceramide and S1P).

Authors:  Guanghu Wang; Erhard Bieberich
Journal:  Adv Biol Regul       Date:  2018-09-22

Review 4.  Sphingolipids in embryonic development, cell cycle regulation, and stemness - Implications for polyploidy in tumors.

Authors:  Christina Voelkel-Johnson
Journal:  Semin Cancer Biol       Date:  2021-01-08       Impact factor: 17.012

Review 5.  Functional Lipids in Autoimmune Inflammatory Diseases.

Authors:  Michele Dei Cas; Gabriella Roda; Feng Li; Francesco Secundo
Journal:  Int J Mol Sci       Date:  2020-04-27       Impact factor: 5.923

Review 6.  Bioactive Lipid Signaling in Cardiovascular Disease, Development, and Regeneration.

Authors:  Aaron H Wasserman; Manigandan Venkatesan; Aitor Aguirre
Journal:  Cells       Date:  2020-06-03       Impact factor: 6.600

Review 7.  Sphingolipids in Obesity and Correlated Co-Morbidities: The Contribution of Gender, Age and Environment.

Authors:  Enrica Torretta; Pietro Barbacini; Nasser M Al-Daghri; Cecilia Gelfi
Journal:  Int J Mol Sci       Date:  2019-11-24       Impact factor: 5.923

8.  Neutral Ceramidase Is Required for the Reproduction of Brown Planthopper, Nilaparvata lugens (Stål).

Authors:  Xiao-Xiao Shi; Mu-Fei Zhu; Ni Wang; Yuan-Jie Huang; Min-Jing Zhang; Chao Zhang; Soomro A Ali; Wen-Wu Zhou; Chuanxi Zhang; Cungui Mao; Zeng-Rong Zhu
Journal:  Front Physiol       Date:  2021-02-24       Impact factor: 4.566

Review 9.  The Many Facets of Sphingolipids in the Specific Phases of Acute Inflammatory Response.

Authors:  Sabine Grösch; Alice V Alessenko; Elisabetta Albi
Journal:  Mediators Inflamm       Date:  2018-02-06       Impact factor: 4.711
  9 in total

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