Eleni A Georgakopoulou1, Marina D Achtari2. 1. Oral Medicine Center, Athens, Greece. 2. Dental Clinic, Penteli Children's General Hospital, Athens, Greece.
Abstract
BACKGROUND: Oral lichen planus is a chronic inflammatory disease of unknown etiology. It is characterized by notable heterogeneity in clinical presentation and behavior. MAIN OBSERVATIONS: We describe 3 patients with lichenoid lesions of the upper lip and upper anterior gingiva. These cases probably represent a clinical subtype of lichenoid lesions associated with microbial antigenicity and are characterized by persistency. All three patients had a long history of previous ineffective treatments and all three showed an excellent response to a combination of clarithromycin (2 x 250 mg/day) and prednisolone (15 mg/day). CONCLUSION: The combination of clarithromycin and prednisolone may be considered as an alternative intervention in patients with lichenoid lesions of the upper lip and upper anterior gingiva.
BACKGROUND: Oral lichen planus is a chronic inflammatory disease of unknown etiology. It is characterized by notable heterogeneity in clinical presentation and behavior. MAIN OBSERVATIONS: We describe 3 patients with lichenoid lesions of the upper lip and upper anterior gingiva. These cases probably represent a clinical subtype of lichenoid lesions associated with microbial antigenicity and are characterized by persistency. All three patients had a long history of previous ineffective treatments and all three showed an excellent response to a combination of clarithromycin (2 x 250 mg/day) and prednisolone (15 mg/day). CONCLUSION: The combination of clarithromycin and prednisolone may be considered as an alternative intervention in patients with lichenoid lesions of the upper lip and upper anterior gingiva.
Authors: Eleni A Georgakopoulou; Marina D Achtari; Michael Achtaris; Periklis G Foukas; Athanassios Kotsinas Journal: J Biomed Biotechnol Date: 2012-05-17