| Literature DB >> 28539275 |
Ying Liu1, Jinguang Liu1, Jun Liang1, Meiying Zhang1, Zhe Li1, Zhi Wang1, Beilei Dang1, Nianping Feng2.
Abstract
Wheat germ agglutinin-modified lipid-polymer hybrid nanoparticles (WGA-LPNs) promote cellular uptake after oral delivery via receptor-mediated endocytosis and bioadhesion. Understanding the mucosal transport of WGA-LPNs would help to improve bioavailability and ensure therapeutic efficacy. In this study, WGA-LPNs interacted with mucin, forming larger agglomerates with intact core-shell structure. The interaction of WGA-LPNs with mucin improved enterocyte endocytosis in Caco-2 cells. An in situ intestinal diffusion study in mice confirmed that WGA-LPNs reached enterocytes and underwent endocytosis, despite interference from mucin. Importantly, oral bioavailability of oridonin-loaded WGA-LPNs increased by 1.96-fold compared with that of LPNs. Furthermore, oral administration of WGA-LPNs inhibited tumor growth in HepG2 xenograft nude mice. In addition to elucidating interactions between WGA-LPNs and mucin, these results indicated that WGA-LPNs might act as promising nanocarriers for oral delivery of drugs.Entities:
Keywords: Antitumor effect; Bioavailability; Mucus diffusion; Wheat germ agglutinin-modified lipid–polymer hybrid nanoparticles
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Year: 2017 PMID： 28539275 DOI： 10.1016/j.nano.2017.05.003
Source DB: PubMed Journal: Nanomedicine ISSN： 1549-9634 Impact factor: 5.307