Cleuber Rodrigo de Souza Bueno1, Mizael Pereira2, Idvaldo Aparecido3, Rogerio Leone Buchaim4, Jesus Carlos Andreo5, Antônio de Castro Rodrigues6, Geraldo Marco7. 1. Graduate student, Department of Biological Sciences, Universidade do Sagrado Coração (USC), Bauru-SP, Brazil. Technical procedures; acquisition, analysis and interpretation of data; histopathological examinations; manuscript preparation. 2. MSc, Department of Biological Sciences (Anatomy), Faculdade de Odontologia de Bauru, Universidade de São Paulo (FOB-USP), Bauru-SP, Brazil. Analysis and interpretation of data, histopathological examinations, manuscript preparation and writing. 3. MSc, Department of Biological Sciences (Anatomy), FOB-USP, Bauru-SP, Brazil. Acquisition of data, technical procedures. 4. PhD, Associate Professor, Department of Biological Sciences (Anatomy), FOB-USP, Bauru-SP, Brazil. Scientific and intellectual content of the study, statitics analysis. 5. PhD, Full Professor, Department of Biological Sciences (Anatomy), FOB-USP, Bauru-SP, Brazil. Scientific and intellectual content of the study. 6. PhD, Associate Professor, Department of Biological Sciences (Anatomy), FOB-USP, Bauru-SP, Brazil. Conception, design, scientific and intellectual content of the study; final approval. 7. PhD, Associate Professor, Department of Biological Sciences, USC, Bauru-SP, Brazil. Conception and design of the study, critical revision, final approval.
Abstract
PURPOSE: : To compare the functional result of standart vein grafts and inside-out vein graft technique on sciatic nerve repair. METHODS: : We used 24 male Wistar rats divided into 4 groups: control group (CG), standard vein graft group (SVG), Inside-out vein graft group (IOVG) and denervated Group (DG). SVG, IOVG and DG underwent total section of the sciatic nerve, SVG and IOVG however underwent nerve repair surgery using a graft with normal jugular vein and inside-out jugular vein, respectively. Histological analysis of the soleus and Extensor Digitorum Longus (EDL), and Sciatic Functional Index were used to compare the results after 6 weeks. RESULTS: : Both grafts acted favorably in muscle recovery and improved functionality; They were similar in all parameters, however, in more points SVG achieved similar to the CG, in the other hand IOVG more times was similar to DG. Fact that makes the graft with normal vein the most viable option between the two options. CONCLUSION: : Both types of grafts acted beneficially wherein the graft normal vein has proved to be the best option.
PURPOSE: : To compare the functional result of standart vein grafts and inside-out vein graft technique on sciatic nerve repair. METHODS: : We used 24 male Wistar rats divided into 4 groups: control group (CG), standard vein graft group (SVG), Inside-out vein graft group (IOVG) and denervated Group (DG). SVG, IOVG and DG underwent total section of the sciatic nerve, SVG and IOVG however underwent nerve repair surgery using a graft with normal jugular vein and inside-out jugular vein, respectively. Histological analysis of the soleus and Extensor Digitorum Longus (EDL), and Sciatic Functional Index were used to compare the results after 6 weeks. RESULTS: : Both grafts acted favorably in muscle recovery and improved functionality; They were similar in all parameters, however, in more points SVG achieved similar to the CG, in the other hand IOVG more times was similar to DG. Fact that makes the graft with normal vein the most viable option between the two options. CONCLUSION: : Both types of grafts acted beneficially wherein the graft normal vein has proved to be the best option.
Authors: Maxime Bonnet; Gaëlle Guiraudie-Capraz; Tanguy Marqueste; Stéphane Garcia; Charlotte Jaloux; Patrick Decherchi; François Féron Journal: Int J Mol Sci Date: 2020-04-11 Impact factor: 5.923