Enas Anwar1, Gehan Hamdy2, Eman Taher3, Esmat Fawzy4, Sherif Abdulattif5, Mohamed H Attia6. 1. 1 Internal Medicine Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt. 2. 2 Internal Medicine Departments, Faculty of Medicine, Cairo University, Cairo, Egypt. 3. 3 Community Department, Faculty of Medicine, Cairo University, Cairo, Egypt. 4. 4 Clinical and Chemical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt. 5. 5 Anesthesia & ICU Department, Faculty of Medicine, Alazhar University, Cairo, Egypt. 6. 6 Internal Medicine Departments, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Abstract
BACKGROUND: Vitamin D deficiency is a prevalent condition among critically ill patients. Information about the relationship between vitamin D levels and outcomes in the intensive care unit (ICU) is sparse. PURPOSE: To evaluate vitamin D status among critically ill patients and its relevance to severity of illness, ICU stay period, and mortality. METHODS: This prospective multicenter study was conducted in the ICUs of Fayoum, Cairo, Alazhar, and Ain Shams university hospitals. All patients were subjected to interview questionnaire, laboratory investigation, vitamin D level assessment, and severity of illness evaluation using the Acute Physiologic Assessment and Chronic Health Evaluation II (APACHE II) score. RESULTS: In total, 250 patients were included in the study. The median age was 62 (40-73) years, and most patients were male (52%). The median serum level of vitamin D was 19 (7-40.6). Vitamin D was deficient in 197 patients (78.8%) on admission. While we grouped the ICU patients as vitamin D deficient, insufficient, and sufficient, vitamin D-deficient patients had more severe diseases (mean APACHE II score, 44 ± 15; P = .014). Prolonged ICU stay was observed among the deficient group but with no significant association. The overall mortality rate was 6.8%; of these, 70.5% were vitamin D-deficient patients. However, logistic regression analysis demonstrated that vitamin D deficiency was not an independent risk factor for mortality. CONCLUSION: Vitamin D insufficiency is common in critically ill patients (69%); it is associated with more severity of illness, but it is not an independent risk factor for longer ICU stay or mortality.
BACKGROUND:Vitamin D deficiency is a prevalent condition among critically illpatients. Information about the relationship between vitamin D levels and outcomes in the intensive care unit (ICU) is sparse. PURPOSE: To evaluate vitamin D status among critically illpatients and its relevance to severity of illness, ICU stay period, and mortality. METHODS: This prospective multicenter study was conducted in the ICUs of Fayoum, Cairo, Alazhar, and Ain Shams university hospitals. All patients were subjected to interview questionnaire, laboratory investigation, vitamin D level assessment, and severity of illness evaluation using the Acute Physiologic Assessment and Chronic Health Evaluation II (APACHE II) score. RESULTS: In total, 250 patients were included in the study. The median age was 62 (40-73) years, and most patients were male (52%). The median serum level of vitamin D was 19 (7-40.6). Vitamin D was deficient in 197 patients (78.8%) on admission. While we grouped the ICU patients as vitamin D deficient, insufficient, and sufficient, vitamin D-deficient patients had more severe diseases (mean APACHE II score, 44 ± 15; P = .014). Prolonged ICU stay was observed among the deficient group but with no significant association. The overall mortality rate was 6.8%; of these, 70.5% were vitamin D-deficient patients. However, logistic regression analysis demonstrated that vitamin D deficiency was not an independent risk factor for mortality. CONCLUSION:Vitamin Dinsufficiency is common in critically illpatients (69%); it is associated with more severity of illness, but it is not an independent risk factor for longer ICU stay or mortality.
Entities:
Keywords:
critical illness; critically ill patients; hospital stay period; intensive care units; length of stay; mortality; vitamin D; vitamin D deficiency
Authors: Jared A Jaffey; Jodi Matheson; Kate Shumway; Christina Pacholec; Tarini Ullal; Lindsay Van den Bossche; Hille Fieten; Randy Ringold; Keun Jung Lee; Amy E DeClue Journal: PLoS One Date: 2020-12-16 Impact factor: 3.240
Authors: Taqwa Bushnaq; Fadiyah Algethami; Alaa Qadhi; Reham Mustafa; Khloud Ghafouri; Wedad Azhar; Asma Al Malki Journal: Int J Environ Res Public Health Date: 2022-02-08 Impact factor: 3.390