Huimin Zhang1,2, Limin Jin3, Tonglu Mu4, Yingying Fan5, Haiyang Zhang6, Yuhua Zhu7, Xujie Mao7, Rong Li1, Siyuan Tang2. 1. a College of nursing , Xinxiang Medical University , Xinxiang , Henan, China. 2. b Xiang Ya Nursing School of Central South University, Xiangya Nursing College in Central South University , Hunan Province , China. 3. c Department of Neurology , The First Hospital of Zhengzhou University , Zhengzhou , China. 4. d Department of Internal Medicine-Neurology , Anyang District Hospital , Puyang City , Henan Province, China. 5. e First Affiliated Hospital of Xinxiang Medical College , Weihui , Henan, China. 6. f Department of Pediatric Surgery , First Affiliated Hospital of Xinxiang Medical College , Weihui , Henan, China. 7. g Department of Nursing , First Affiliated Hospital of Xinxiang Medical College , Weihui , Henan, China.
Abstract
OBJECTIVES: The aim of this study was to investigate the impact of CYP4A11 single-nucleotide polymorphisms (SNP), additional gene-gene and gene-environment interactions on essential hypertension (EH) risk. METHODS: A total of 1648 participants (788 males, 860 females), with a mean age of 56.1 ± 14.1 years old, were selected, including 820 EH patients and 828 normotension subjects. Logistic regression was performed to investigate association of SNPs within CYP4A11 gene with high DBP, high SBP and EH risk, and generalized multifactor dimensionality reduction (GMDR) was used to analyze the gene-gene interaction and gene-smoking interaction. RESULTS: Logistic regression analysis showed that EH risk was significantly higher in carriers of C allele of the rs1126742 polymorphism than those with TT genotype (TC+CC versus TT, adjusted OR (95%CI) = 1.56 (1.24-1.91). In addition, we also found that EH risk was also significantly higher in carriers of G allele of the rs3890011polymorphism than those with CC genotype (CG+ GG versus CC, adjusted OR (95%CI) = 1.31 (1.15-2.03). GMDR analysis indicated a potential gene-gene interaction between rs1126742 and rs3890011 and a gene-environment interaction between rs1126742 and smoking. We found that subjects with TC or CC of rs1126742 and CG or GG of rs3890011genotype have the highest EH risk, OR (95%CI) was 2.52 (1.28-3.57). Smokers with TC or CC of rs1126742 genotype have the highest EH risk, OR (95%CI) was 2.20 (1.28-3.40). CONCLUSIONS: Gene-gene interaction between rs1126742 and rs3890011 and gene-environment interaction between rs1126742 and smoking were associated with increased EH risk.
OBJECTIVES: The aim of this study was to investigate the impact of CYP4A11 single-nucleotide polymorphisms (SNP), additional gene-gene and gene-environment interactions on essential hypertension (EH) risk. METHODS: A total of 1648 participants (788 males, 860 females), with a mean age of 56.1 ± 14.1 years old, were selected, including 820 EH patients and 828 normotension subjects. Logistic regression was performed to investigate association of SNPs within CYP4A11 gene with high DBP, high SBP and EH risk, and generalized multifactor dimensionality reduction (GMDR) was used to analyze the gene-gene interaction and gene-smoking interaction. RESULTS: Logistic regression analysis showed that EH risk was significantly higher in carriers of C allele of the rs1126742 polymorphism than those with TT genotype (TC+CC versus TT, adjusted OR (95%CI) = 1.56 (1.24-1.91). In addition, we also found that EH risk was also significantly higher in carriers of G allele of the rs3890011polymorphism than those with CC genotype (CG+ GG versus CC, adjusted OR (95%CI) = 1.31 (1.15-2.03). GMDR analysis indicated a potential gene-gene interaction between rs1126742 and rs3890011 and a gene-environment interaction between rs1126742 and smoking. We found that subjects with TC or CC of rs1126742 and CG or GG of rs3890011genotype have the highest EH risk, OR (95%CI) was 2.52 (1.28-3.57). Smokers with TC or CC of rs1126742 genotype have the highest EH risk, OR (95%CI) was 2.20 (1.28-3.40). CONCLUSIONS: Gene-gene interaction between rs1126742 and rs3890011 and gene-environment interaction between rs1126742 and smoking were associated with increased EH risk.
Authors: Shashank Shekhar; Kevin Varghese; Man Li; Letao Fan; George W Booz; Richard J Roman; Fan Fan Journal: Int J Mol Sci Date: 2019-09-11 Impact factor: 5.923
Authors: Ezekiel Gonzalez-Fernandez; Daniel Staursky; Kathryn Lucas; Bond V Nguyen; Man Li; Yedan Liu; Chad Washington; Lique M Coolen; Fan Fan; Richard J Roman Journal: Front Neurol Date: 2020-09-04 Impact factor: 4.003