L Heine1,2, B Tillmann1, M Hauet1,3, A Juliat1,4, A Dubois4, S Laureys2, M Kandel3, J Plailly5, J Luauté4,6, F Perrin1. 1. a Auditory Cognition and Psychoacoustics Team, Lyon Neuroscience Research Center , Lyon , France. 2. b Coma Science Group, GIGA, Neurology Department , University and University Hospital of Liège , Liège , Belgium. 3. c Centre Germaine Revel, Saint-Maurice-sur-Dargoire , France. 4. d Hospices Civils de Lyon, Service de Rééducation Neurologique, Mouvement et Handicap, Lyon University Hospital, Lyon , France. 5. e Coding and Olfactory Memory Team, Lyon Neuroscience Research Center , Lyon , France. 6. f Integrative Multisensory Perception Action and Cognition Team, Lyon Neuroscience Research Center , Lyon , France.
Abstract
BACKGROUND: Reliable evaluation of patients with unresponsive wakefulness syndrome (UWS) or in a minimally conscious state (MCS) remains a major challenge. It has been suggested that the expression of residual cerebral function could be improved by allowing patients to listen to their favourite music. However, the potential effect of music on behavioural responsiveness, as well as the effect of preferred stimuli in other sensory modalities (e.g. olfaction), remain poorly understood. OBJECTIVE: The aim of our study was to investigate the effect of sensory modality (auditory versus olfactory) and preference (preferred versus neutral) of the test stimuli on patients' subsequent performance on the Coma Recovery Scale-Revised (CRS-R). RESEARCH DESIGN: Within-subject design because of inter-individual differences between patients. METHODS AND PROCEDURES: We studied four items from the CRS-R (visual pursuit using a mirror, auditory localization of the own name and two movements to command) in 13 patients (7 MCS; 6 UWS). MAIN OUTCOMES AND RESULTS: Auditory stimuli triggered higher responsiveness compared to olfactory stimuli, and preferred stimuli were followed by higher scores than did neutral stimuli. CONCLUSIONS: Findings suggest that preferred auditory stimuli at the bedside contribute to the expression of residual function and could improve the diagnostic assessment.
BACKGROUND: Reliable evaluation of patients with unresponsive wakefulness syndrome (UWS) or in a minimally conscious state (MCS) remains a major challenge. It has been suggested that the expression of residual cerebral function could be improved by allowing patients to listen to their favourite music. However, the potential effect of music on behavioural responsiveness, as well as the effect of preferred stimuli in other sensory modalities (e.g. olfaction), remain poorly understood. OBJECTIVE: The aim of our study was to investigate the effect of sensory modality (auditory versus olfactory) and preference (preferred versus neutral) of the test stimuli on patients' subsequent performance on the Coma Recovery Scale-Revised (CRS-R). RESEARCH DESIGN: Within-subject design because of inter-individual differences between patients. METHODS AND PROCEDURES: We studied four items from the CRS-R (visual pursuit using a mirror, auditory localization of the own name and two movements to command) in 13 patients (7 MCS; 6 UWS). MAIN OUTCOMES AND RESULTS: Auditory stimuli triggered higher responsiveness compared to olfactory stimuli, and preferred stimuli were followed by higher scores than did neutral stimuli. CONCLUSIONS: Findings suggest that preferred auditory stimuli at the bedside contribute to the expression of residual function and could improve the diagnostic assessment.
Authors: Michael Francis Norwood; Ali Lakhani; David Phillip Watling; Chelsea Hannah Marsh; Heidi Zeeman Journal: Neuropsychol Rev Date: 2022-09-02 Impact factor: 6.940