Jianqin Lei1,2,3, Siva Balasubramanian1,2, Nizar Saleh Abdelfattah1,2, Muneeswar G Nittala1,2, SriniVas R Sadda4,5. 1. Doheny Image Reading Center, Doheny Eye Institute, 1350 San Pablo St., DVRC211, Los Angeles, CA, 90033, USA. 2. Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. 3. 1st Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. 4. Doheny Image Reading Center, Doheny Eye Institute, 1350 San Pablo St., DVRC211, Los Angeles, CA, 90033, USA. ssadda@doheny.org. 5. Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. ssadda@doheny.org.
Abstract
PURPOSE: To develop a simple, clinically practical, optical coherence tomography (OCT)-based scoring system for early age-related macular degeneration (AMD) to prognosticate risk for progression to late AMD. METHODS: We retrospectively reviewed OCT images (512 × 128 macular cube, Cirrus) from 138 patients diagnosed of early AMD in at least one eye and follow-up of at least 12 months. For patients with early AMD in both eyes, only the right eye was chosen as the study eye for longitudinal assessment. Scans were graded on four SD-OCT criteria associated with disease progression in previous studies: drusen volume within a central 3-mm circle ≥0.03 mm3, intraretinal hyperreflective foci (HRF), hyporeflective foci (hRF) within a drusenoid lesion (DL), and subretinal drusenoid deposits (SDD). Each criterion was assigned one point. For risk assessment of the study eye, the baseline status of the fellow eye was also considered, and thus these four features were also assessed in the fellow eye. The number of risk factors were summed for both eyes, yielding a total score (TS) of 0 to 8 for each patient. A fellow eye with evident choroidal neovascularization (CNV) or atrophy automatically received 4 points. Scores were then grouped into four categories to facilitate comparative analysis: I. (TS of 0, 1, 2), II. (TS of 3, 4), III. (TS of 5, 6) and IV. (TS of 7, 8). Correlation of baseline category assignment with progression to late AMD (defined as the presence of atrophy or CNV on OCT) by the last follow-up visit was evaluated with logistic regression analysis. RESULTS: The rate of progression to late AMD was 39.9% (55/138). Progression rates by category (I to IV) were 0, 14.3, 47.5, and 73.3%, respectively. Logistic regression analysis showed risk of progression to late AMD was 3.0 times (95% CI: 1.2-7.9) higher for an eye assigned to category IV than for an eye in category III and 16.4 (95% CI: 4.7-58.8) times higher than for an eye in category II. CONCLUSIONS: A simple scoring system relevant to prognosis for early AMD, and practical for use in a busy clinic, can be developed using SD-OCT criteria alone.
PURPOSE: To develop a simple, clinically practical, optical coherence tomography (OCT)-based scoring system for early age-related macular degeneration (AMD) to prognosticate risk for progression to late AMD. METHODS: We retrospectively reviewed OCT images (512 × 128 macular cube, Cirrus) from 138 patients diagnosed of early AMD in at least one eye and follow-up of at least 12 months. For patients with early AMD in both eyes, only the right eye was chosen as the study eye for longitudinal assessment. Scans were graded on four SD-OCT criteria associated with disease progression in previous studies: drusen volume within a central 3-mm circle ≥0.03 mm3, intraretinal hyperreflective foci (HRF), hyporeflective foci (hRF) within a drusenoid lesion (DL), and subretinal drusenoid deposits (SDD). Each criterion was assigned one point. For risk assessment of the study eye, the baseline status of the fellow eye was also considered, and thus these four features were also assessed in the fellow eye. The number of risk factors were summed for both eyes, yielding a total score (TS) of 0 to 8 for each patient. A fellow eye with evident choroidal neovascularization (CNV) or atrophy automatically received 4 points. Scores were then grouped into four categories to facilitate comparative analysis: I. (TS of 0, 1, 2), II. (TS of 3, 4), III. (TS of 5, 6) and IV. (TS of 7, 8). Correlation of baseline category assignment with progression to late AMD (defined as the presence of atrophy or CNV on OCT) by the last follow-up visit was evaluated with logistic regression analysis. RESULTS: The rate of progression to late AMD was 39.9% (55/138). Progression rates by category (I to IV) were 0, 14.3, 47.5, and 73.3%, respectively. Logistic regression analysis showed risk of progression to late AMD was 3.0 times (95% CI: 1.2-7.9) higher for an eye assigned to category IV than for an eye in category III and 16.4 (95% CI: 4.7-58.8) times higher than for an eye in category II. CONCLUSIONS: A simple scoring system relevant to prognosis for early AMD, and practical for use in a busy clinic, can be developed using SD-OCT criteria alone.
Authors: Marcela Marsiglia; Sucharita Boddu; Srilaxmi Bearelly; Luna Xu; Barry E Breaux; K Bailey Freund; Lawrence A Yannuzzi; R Theodore Smith Journal: Invest Ophthalmol Vis Sci Date: 2013-11-08 Impact factor: 4.799
Authors: Nizar Saleh Abdelfattah; Hongyang Zhang; David S Boyer; Philip J Rosenfeld; William J Feuer; Giovanni Gregori; SriniVas R Sadda Journal: Invest Ophthalmol Vis Sci Date: 2016-04 Impact factor: 4.799
Authors: Joseph G Christenbury; Francisco A Folgar; Rachelle V O'Connell; Stephanie J Chiu; Sina Farsiu; Cynthia A Toth Journal: Ophthalmology Date: 2013-01-23 Impact factor: 12.079
Authors: Neil M Bressler; Susan B Bressler; Nathan G Congdon; Frederick L Ferris; David S Friedman; Ronald Klein; Anne S Lindblad; Roy C Milton; Johanna M Seddon Journal: Arch Ophthalmol Date: 2003-11
Authors: Francisco A Folgar; Jessica H Chow; Sina Farsiu; Wai T Wong; Stefanie G Schuman; Rachelle V O'Connell; Katrina P Winter; Emily Y Chew; Thomas S Hwang; Sunil K Srivastava; Molly W Harrington; Traci E Clemons; Cynthia A Toth Journal: Invest Ophthalmol Vis Sci Date: 2012-07-09 Impact factor: 4.799
Authors: Luis de Sisternes; Noah Simon; Robert Tibshirani; Theodore Leng; Daniel L Rubin Journal: Invest Ophthalmol Vis Sci Date: 2014-10-09 Impact factor: 4.799
Authors: Caroline Brandl; Christiane Brücklmayer; Felix Günther; Martina E Zimmermann; Helmut Küchenhoff; Horst Helbig; Bernhard H F Weber; Iris M Heid; Klaus J Stark Journal: Invest Ophthalmol Vis Sci Date: 2019-04-01 Impact factor: 4.799
Authors: Patricia T A Bui; Gregor S Reiter; Maria Fabianska; Sebastian M Waldstein; Christoph Grechenig; Hrvoje Bogunovic; Mustafa Arikan; Ursula Schmidt-Erfurth Journal: Eye (Lond) Date: 2021-08-16 Impact factor: 4.456
Authors: Benjamin S Echols; Mark E Clark; Thomas A Swain; Ling Chen; Deepayan Kar; Yuhua Zhang; Kenneth R Sloan; Gerald McGwin; Ramya Singireddy; Christian Mays; David Kilpatrick; Jason N Crosson; Cynthia Owsley; Christine A Curcio Journal: Ophthalmol Retina Date: 2020-05-07
Authors: Yingying Shi; Qinqin Zhang; Hao Zhou; Liang Wang; Zhongdi Chu; Xiaoshuang Jiang; Mengxi Shen; Marie Thulliez; Cancan Lyu; William Feuer; Luis de Sisternes; Mary K Durbin; Giovanni Gregori; Ruikang K Wang; Philip J Rosenfeld Journal: Am J Ophthalmol Date: 2020-12-24 Impact factor: 5.258
Authors: Malini Veerappan Pasricha; Vincent Tai; Karim Sleiman; Katrina Winter; Stephanie J Chiu; Sina Farsiu; Sandra S Stinnett; Eleonora M Lad; Wai T Wong; Emily Y Chew; Cynthia A Toth Journal: Ophthalmol Retina Date: 2020-12-22