| Literature DB >> 28533187 |
Arnaud Machelart1, Ok-Ryul Song1, Eik Hoffmann1, Priscille Brodin2.
Abstract
Tuberculosis (TB) remains a leading global health problem that is exacerbated by the emergence of multidrug and extensively drug-resistant Mycobacterium tuberculosis strains. Control of the disease requires novel therapeutic strategies. Modulating host homeostasis appears to be a promising approach, and recent studies have identified novel potential host targets and compounds that could be investigated for host-directed therapies (HDTs). Moreover, the recent development of intracellular high-throughput phenotypic assays makes it possible to screen large libraries of compounds to identify more rapidly new effectors for mycobacterial elimination. Technological advances combined with the novel HDT concept opens an interesting and promising research area that could ultimately deliver personalized TB treatment.Entities:
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Year: 2017 PMID： 28533187 DOI： 10.1016/j.drudis.2017.05.005
Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851