| Literature DB >> 2853058 |
Abstract
An injection of the excitatory amino acid analogue, N-methyl-D-aspartate (NMDA), in the rat periaqueductal gray resulted in potent analgesia. A prior injection of the NMDA antagonist, (-)-2-amino-7-phosphonoheptanoate (D-AP7), antagonized this action, indicating a receptor-mediated action. NMDA given with morphine potentiated the morphine analgesia while D-AP7 blocked morphine analgesia. These results delineate for the first time a functional role for the NMDA receptor in the control of pain in the mammalian central nervous system.Entities:
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Year: 1988 PMID： 2853058 DOI： 10.1016/0014-2999(88)90201-4
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432