Literature DB >> 28530323

[PAPILLARY THYROID CARCINOMA TREATMENT - IS THE PENDULUM SHIFTING?]

Sagit Stern1,2, Elad Dagan3,2, Eran E Alon3,2, Ziv Gil4,5, Gideon Bachar1,2.   

Abstract

INTRODUCTION: The incidence of papillary thyroid carcinoma has been on the rise in the past few decades while the disease specific mortality remains stable. During prophylactic central neck dissection (level 6), an average of 60% positive occult lymph nodes metastasis are found, hence the justification for performing a prophylactic central neck dissection. The opponents for performing neck dissection claim that the disease specific mortality is low regardless of the operation and that adding a neck dissection will, significantly, increase surgical morbidity. Guidelines regarding prophylactic central neck dissection differ between countries and cultures. The difficulty to determine unequivocal guidelines is due to the scarcity of randomized controlled trials to assess the effectiveness of prophylactic neck dissection. In this literature review we will explore data in favor and against prophylactic central neck dissection for patients with papillary thyroid carcinoma.

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Year:  2016        PMID: 28530323

Source DB:  PubMed          Journal:  Harefuah        ISSN: 0017-7768


  1 in total

1.  DPP4 gene silencing inhibits proliferation and epithelial-mesenchymal transition of papillary thyroid carcinoma cells through suppression of the MAPK pathway.

Authors:  X Hu; S Chen; C Xie; Z Li; Z Wu; Z You
Journal:  J Endocrinol Invest       Date:  2021-01-02       Impact factor: 4.256

  1 in total

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