Literature DB >> 28529830

ADP-ribosyl cyclases regulate early development of the sea urchin.

Latha Ramakrishnan1, Kevin Uhlinger2, Leslie Dale1, Amro Hamdoun2, Sandip Patel1.   

Abstract

ADP-ribosyl cyclases are multifunctional enzymes involved in the metabolism of nucleotide derivatives necessary for Ca2+ signalling such as cADPR and NAADP. Although Ca2+ signalling is a critical regulator of early development, little is known of the role of ADP-ribosyl cyclases during embryogenesis. Here we analyze the expression, activity and function of ADP-ribosyl cyclases in the embryo of the sea urchin - a key organism for study of both Ca2+ signalling and embryonic development. ADP-ribosyl cyclase isoforms (SpARC1-4) showed unique changes in expression during early development. These changes were associated with an increase in the ratio of cADPR:NAADP production. Over-expression of SpARC4 (a preferential cyclase) disrupted gastrulation. Our data highlight the importance of ADP-ribosyl cyclases during embryogenesis.

Entities:  

Keywords:  ADP-ribosyl cyclase; NAADP; cyclic ADP-ribose; early development; gastrulation

Year:  2016        PMID： 28529830      PMCID： PMC5435102          DOI： 10.1166/msr.2016.1052

Source DB:  PubMed          Journal:  Messenger (Los Angel)


  34 in total

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Review 3.  Ca2+ signaling and early embryonic patterning during the blastula and gastrula periods of zebrafish and Xenopus development.

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Review 5.  Acidic calcium stores open for business: expanding the potential for intracellular Ca2+ signaling.

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Journal:  Trends Cell Biol       Date:  2010-03-18       Impact factor: 20.808

6.  Metabolism of the novel Ca2+-mobilizing messenger nicotinic acid-adenine dinucleotide phosphate via a 2'-specific Ca2+-dependent phosphatase.

Authors:  Georgina Berridge; Rainer Cramer; Antony Galione; Sandip Patel
Journal:  Biochem J       Date:  2002-07-01       Impact factor: 3.857

7.  Molecular characterization of a novel cell surface ADP-ribosyl cyclase from the sea urchin.

Authors:  Dev Churamani; Michael J Boulware; Latha Ramakrishnan; Timothy J Geach; Andrew C R Martin; Victor D Vacquier; Jonathan S Marchant; Leslie Dale; Sandip Patel
Journal:  Cell Signal       Date:  2008-09-13       Impact factor: 4.315

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Journal:  Science       Date:  1993-07-16       Impact factor: 47.728

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Authors:  D L Clapper; T F Walseth; P J Dargie; H C Lee
Journal:  J Biol Chem       Date:  1987-07-15       Impact factor: 5.157

10.  Nicotinic acid adenine dinucleotide phosphate (NAADP) degradation by alkaline phosphatase.

Authors:  Frederike Schmid; Ralf Fliegert; Tim Westphal; Andreas Bauche; Andreas H Guse
Journal:  J Biol Chem       Date:  2012-07-31       Impact factor: 5.157
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  2 in total

1.  A Special Issue of Messenger 2016.

Authors:  Sandip Patel
Journal:  Messenger (Los Angel)       Date:  2016-06

2.  Specific cyclic ADP-ribose phosphohydrolase obtained by mutagenic engineering of Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase.

Authors:  João Meireles Ribeiro; José Canales; Alicia Cabezas; Joaquim Rui Rodrigues; Rosa María Pinto; Iralis López-Villamizar; María Jesús Costas; José Carlos Cameselle
Journal:  Sci Rep       Date:  2018-01-18       Impact factor: 4.379
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