Literature DB >> 28529828

Two-Pore Channels and Parkinson's Disease: Where's the Link?

Pilar Rivero-Ríos1, Belén Fernández1, Jesús Madero-Pérez1, María Romo Lozano1, Sabine Hilfiker1.   

Abstract

Two-pore channels are endolysosomal Ca2+ release channels involved in proper trafficking to and from those organelles. They are the likely targets for the Ca2+-mobilizing messenger NAADP, and are further regulated by a variety of mechanisms including phosphoinositide levels and Rab proteins. As discussed here, recent studies highlight a role for these channels in the pathomechanism(s) underlying Parkinson's disease, with important implications for possible alternative treatment strategies.

Entities:  

Keywords:  Calcium; Iron; LRRK2; NAADP; Parkinson’s Disease; Rab Proteins; TPCN1; TPCN2

Year:  2016        PMID： 28529828      PMCID： PMC5436604          DOI： 10.1166/msr.2016.1051

Source DB:  PubMed          Journal:  Messenger (Los Angel)


  78 in total

1.  Ca2+ accumulation into acidic organelles mediated by Ca2+- and vacuolar H+-ATPases in human platelets.

Authors:  José J López; Cristina Camello-Almaraz; José A Pariente; Ginés M Salido; Juan A Rosado
Journal:  Biochem J       Date:  2005-08-15       Impact factor: 3.857

Review 2.  Cellular functions of LRRK2 implicate vesicular trafficking pathways in Parkinson's disease.

Authors:  Mark R Cookson
Journal:  Biochem Soc Trans       Date:  2016-12-15       Impact factor: 5.407

3.  Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases.

Authors:  Archana Jha; Malini Ahuja; Sandip Patel; Eugen Brailoiu; Shmuel Muallem
Journal:  EMBO J       Date:  2014-02-05       Impact factor: 11.598

Review 4.  A primer of NAADP-mediated Ca(2+) signalling: From sea urchin eggs to mammalian cells.

Authors:  Antony Galione
Journal:  Cell Calcium       Date:  2014-10-07       Impact factor: 6.817

5.  Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP.

Authors:  Patricia Gómez-Suaga; Berta Luzón-Toro; Dev Churamani; Ling Zhang; Duncan Bloor-Young; Sandip Patel; Philip G Woodman; Grant C Churchill; Sabine Hilfiker
Journal:  Hum Mol Genet       Date:  2011-10-19       Impact factor: 6.150

6.  Both RyRs and TPCs are required for NAADP-induced intracellular Ca²⁺ release.

Authors:  Julia V Gerasimenko; Richard M Charlesworth; Mark W Sherwood; Pawel E Ferdek; Katsuhiko Mikoshiba; John Parrington; Ole H Petersen; Oleg V Gerasimenko
Journal:  Cell Calcium       Date:  2015-06-10       Impact factor: 6.817

7.  NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing.

Authors:  Lianne C Davis; Anthony J Morgan; Ji-Li Chen; Charlotte M Snead; Duncan Bloor-Young; Eugene Shenderov; Megan N Stanton-Humphreys; Stuart J Conway; Grant C Churchill; John Parrington; Vincenzo Cerundolo; Antony Galione
Journal:  Curr Biol       Date:  2012-11-21       Impact factor: 10.834

8.  Ca2+/H+ exchange by acidic organelles regulates cell migration in vivo.

Authors:  Manuela Melchionda; Jon K Pittman; Roberto Mayor; Sandip Patel
Journal:  J Cell Biol       Date:  2016-03-21       Impact factor: 10.539

9.  Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.

Authors:  Alexandria Beilina; Iakov N Rudenko; Alice Kaganovich; Laura Civiero; Hien Chau; Suneil K Kalia; Lorraine V Kalia; Evy Lobbestael; Ruth Chia; Kelechi Ndukwe; Jinhui Ding; Mike A Nalls; Maciej Olszewski; David N Hauser; Ravindran Kumaran; Andres M Lozano; Veerle Baekelandt; Lois E Greene; Jean-Marc Taymans; Elisa Greggio; Mark R Cookson
Journal:  Proc Natl Acad Sci U S A       Date:  2014-02-07       Impact factor: 11.205

10.  Rab11 modulates α-synuclein-mediated defects in synaptic transmission and behaviour.

Authors:  Carlo Breda; Marie L Nugent; Jasper G Estranero; Charalambos P Kyriacou; Tiago F Outeiro; Joern R Steinert; Flaviano Giorgini
Journal:  Hum Mol Genet       Date:  2014-10-09       Impact factor: 6.150
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  2 in total

Review 1.  Lysosomal Ion Channels as Decoders of Cellular Signals.

Authors:  Ping Li; Mingxue Gu; Haoxing Xu
Journal:  Trends Biochem Sci       Date:  2018-11-10       Impact factor: 13.807

2.  Two-pore channel blockade by phosphoinositide kinase inhibitors YM201636 and PI-103 determined by a histidine residue near pore-entrance.

Authors:  Canwei Du; Xin Guan; Jiusheng Yan
Journal:  Commun Biol       Date:  2022-07-23
  2 in total

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