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Literature DB >> 2852914

Synergy of antiviral actions of TNF and IFN-gamma: evidence for a major role of TNF-induced IFN-beta.

T K Hughes¹, T A Kaspar, D H Coppenhaver.

Abstract

Tumor necrosis factor (TNF) potentiates the antiviral activity of interferon-gamma (IFN-gamma) directly and through induction of IFN-beta in HEp-2 cells. Antibody to IFN-beta inhibits a large component of the TNF and IFN-gamma synergy and immunoreactive IFN-beta can be detected in the supernatant fluids of TNF-treated HEp-2 cells. Furthermore, the kinetics of development of this synergy and its susceptibility to inhibition by antibody to IFN-beta is demonstrated.

Entities: Disease Gene

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Year: 1988 PMID： 2852914 DOI： 10.1016/0166-3542(88)90010-1

Source DB: PubMed Journal: Antiviral Res ISSN： 0166-3542 Impact factor: 5.970

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Cited

7 in total

1. Blockade of virus infection by human CD4+ T cells via a cytokine relay network.

Authors: Ann M Davis; Kristan A Hagan; Loderick A Matthews; Gagan Bajwa; Michelle A Gill; Michael Gale; J David Farrar
Journal: J Immunol Date: 2008-05-15 Impact factor: 5.422

2. Transcriptome analysis reveals human cytomegalovirus reprograms monocyte differentiation toward an M1 macrophage.

Authors: Gary Chan; Elizabeth R Bivins-Smith; M Shane Smith; Patrick M Smith; Andrew D Yurochko
Journal: J Immunol Date: 2008-07-01 Impact factor: 5.422

3. The addition of tumor necrosis factor plus beta interferon induces a novel synergistic antiviral state against poxviruses in primary human fibroblasts.

Authors: Eric Bartee; Mohamed R Mohamed; M Cecilia Lopez; Henry V Baker; Grant McFadden
Journal: J Virol Date: 2008-10-29 Impact factor: 5.103

4. Inhibition of interferon gamma induced interleukin 12 production: a potential mechanism for the anti-inflammatory activities of tumor necrosis factor.

Authors: J Hodge-Dufour; M W Marino; M R Horton; A Jungbluth; M D Burdick; R M Strieter; P W Noble; C A Hunter; E Puré
Journal: Proc Natl Acad Sci U S A Date: 1998-11-10 Impact factor: 11.205

Synergy of antiviral actions of TNF and IFN-gamma: evidence for a major role of TNF-induced IFN-beta.

1. Blockade of virus infection by human CD4+ T cells via a cytokine relay network.

2. Transcriptome analysis reveals human cytomegalovirus reprograms monocyte differentiation toward an M1 macrophage.

3. The addition of tumor necrosis factor plus beta interferon induces a novel synergistic antiviral state against poxviruses in primary human fibroblasts.

4. Inhibition of interferon gamma induced interleukin 12 production: a potential mechanism for the anti-inflammatory activities of tumor necrosis factor.

5. Production of interferons and beta-chemokines by placental trophoblasts of HIV-1-infected women.

6. The Antiviral Effects of Jasminin via Endogenous TNF-α and the Underlying TNF-α-Inducing Action.

Review 7. Tumor necrosis factor and interferon: cytokines in harmony.