Literature DB >> 28528799

A multifactorial obesity model developed from nationwide public health exposome data and modern computational analyses.

LisaAnn S Gittner1, Barbara J Kilbourne2, Ravi Vadapalli3, Hafiz M K Khan4, Michael A Langston5.   

Abstract

STATEMENT OF THE PROBLEM: Obesity is both multifactorial and multimodal, making it difficult to identify, unravel and distinguish causative and contributing factors. The lack of a clear model of aetiology hampers the design and evaluation of interventions to prevent and reduce obesity.
METHODS: Using modern graph-theoretical algorithms, we are able to coalesce and analyse thousands of inter-dependent variables and interpret their putative relationships to obesity. Our modelling is different from traditional approaches; we make no a priori assumptions about the population, and model instead based on the actual characteristics of a population. Paracliques, noise-resistant collections of highly-correlated variables, are differentially distilled from data taken over counties associated with low versus high obesity rates. Factor analysis is then applied and a model is developed. RESULTS AND
CONCLUSIONS: Latent variables concentrated around social deprivation, community infrastructure and climate, and especially heat stress were connected to obesity. Infrastructure, environment and community organisation differed in counties with low versus high obesity rates. Clear connections of community infrastructure with obesity in our results lead us to conclude that community level interventions are critical. This effort suggests that it might be useful to study and plan interventions around community organisation and structure, rather than just the individual, to combat the nation's obesity epidemic.
Copyright © 2017 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Factor analysis; Graph-theoretical algorithms; Obesity modelling

Mesh:

Year:  2017        PMID: 28528799      PMCID: PMC5597453          DOI: 10.1016/j.orcp.2017.05.001

Source DB:  PubMed          Journal:  Obes Res Clin Pract        ISSN: 1871-403X            Impact factor:   2.288


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