Jay Agarwal1, Sameep Kadakia2, Abbas Agaimy3, Anna Ogadzanov4, Azita Khorsandi5, Raymond L Chai6. 1. Department of Otolaryngology - Head and Neck Surgery, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, United States. Electronic address: jagarwal@nyee.edu. 2. Department of Otolaryngology - Head and Neck Surgery, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, United States. Electronic address: skadakia@nyee.edu. 3. Department of Pathology, Erlangen University Hospital, Erlangen, Germany. Electronic address: Abbas.agaimy@uk-erlangen.de. 4. Department of Otolaryngology - Head and Neck Surgery, University Hospital of Erlangen, Erlangen, Germany. Electronic address: anna.ogadzanov@uk-erlangen.de. 5. Department of Radiology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, United States. Electronic address: akhorsan@chpnet.org. 6. Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address: raymond.chai@mountsinai.org.
Abstract
BACKGROUND: Pleomorphic liposarcoma (PL) is an exceedingly rare tumor of the head and neck. This aggressive liposarcoma variant portends a poorer prognosis compared to more typical sarcomatous tumors. METHODS: Multi-institutional study including two cases of PL, the first case occurring in the post-auricular region and the second in the cheek with later recurrence within the parotid bed. RESULTS: Both patients were treated surgically with wide local excision. One patient required reoperation to obtain negative margins. The other patient underwent a total parotidectomy with neck dissection for recurrent intraparotid nodal disease. Both patients underwent adjuvant radiotherapy. No patient had evidence of recurrent disease with minimum one year follow-up. CONCLUSION: Although the literature is sparse on this disease, wide surgical extirpation with negative margins and adjuvant radiation is recommended. Increased reports of this pathology can be helpful in providing practitioners with experienced-based information that can aid in early detection and treatment. We present the first case series of PL of the head and neck in the literature.
BACKGROUND: Pleomorphic liposarcoma (PL) is an exceedingly rare tumor of the head and neck. This aggressive liposarcoma variant portends a poorer prognosis compared to more typical sarcomatous tumors. METHODS: Multi-institutional study including two cases of PL, the first case occurring in the post-auricular region and the second in the cheek with later recurrence within the parotid bed. RESULTS: Both patients were treated surgically with wide local excision. One patient required reoperation to obtain negative margins. The other patient underwent a total parotidectomy with neck dissection for recurrent intraparotid nodal disease. Both patients underwent adjuvant radiotherapy. No patient had evidence of recurrent disease with minimum one year follow-up. CONCLUSION: Although the literature is sparse on this disease, wide surgical extirpation with negative margins and adjuvant radiation is recommended. Increased reports of this pathology can be helpful in providing practitioners with experienced-based information that can aid in early detection and treatment. We present the first case series of PL of the head and neck in the literature.
Authors: Tasuku Kiyuna; Yasunori Tome; Takashi Murakami; Kei Kawaguchi; Kentaro Igarashi; Kentaro Miyake; Masuyo Miyake; Yunfeng Li; Scott D Nelson; Sarah M Dry; Arun S Singh; Tara A Russell; Irmina Elliott; Shree Ram Singh; Fuminori Kanaya; Fritz C Eilber; Robert M Hoffman Journal: BMC Cancer Date: 2018-08-20 Impact factor: 4.430