Hiroaki Ikawa1, Masashi Koto2, Ryo Takagi2, Daniel K Ebner3, Azusa Hasegawa2, Kensuke Naganawa2, Toshinao Takenouchi2, Toshitaka Nagao4, Takeshi Nomura5, Takahiko Shibahara6, Hiroshi Tsuji2, Tadashi Kamada2. 1. Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Sciences and Technology, Chiba, Japan; Department of Oral Medicine, Oral and Maxillofacial Surgery, Tokyo Dental College, Japan. Electronic address: ikawa.hiroaki@qst.go.jp. 2. Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Sciences and Technology, Chiba, Japan. 3. Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Sciences and Technology, Chiba, Japan; Brown University Alpert Medical School, Providence, USA. 4. Department of Anatomic Pathology, Tokyo Medical University, Japan. 5. Department of Oral Medicine, Oral and Maxillofacial Surgery, Tokyo Dental College, Japan. 6. Department of Oral and Maxillofacial Surgery, Tokyo Dental College, Japan.
Abstract
PURPOSE: The aim of this study was to evaluate the effect of histological subtypes of head and neck adenoid cystic carcinoma (ACC) on the results of carbon-ion radiotherapy (CIRT). MATERIAL AND METHODS: Of the 113 patients with ACC who were treated with CIRT between December 2006 and July 2013, 100 patients with identified histological subtypes were enrolled in this study. CIRT at a total dose of 57.6 or 64.0Gy (RBE) was administered in 16 fractions. Histological grading was defined as the presence or absence of a solid growth pattern. RESULTS: Median follow-up was 60 months. 5-Year local control (LC), overall survival (OS) and distant metastasis free survival (DMFS) of all patients were 68.6%, 74.8% and 65.7%, respectively. On multivariate analysis, the prescribed dose (p=0.001) and gross tumor volume (p=0.002) were significant independent risk factors for LC. No significant difference for local control of solid/non-solid growth patterns was found (p=0.093). Solid growth pattern was an independent risk factor for both OS (p=0.033) and DMFS (p=0.024). CONCLUSIONS: CIRT appears able to locally control solid growth pattern ACC in the head and neck. Improved intervention is needed to extend DMFS and OS.
PURPOSE: The aim of this study was to evaluate the effect of histological subtypes of head and neck adenoid cystic carcinoma (ACC) on the results of carbon-ion radiotherapy (CIRT). MATERIAL AND METHODS: Of the 113 patients with ACC who were treated with CIRT between December 2006 and July 2013, 100 patients with identified histological subtypes were enrolled in this study. CIRT at a total dose of 57.6 or 64.0Gy (RBE) was administered in 16 fractions. Histological grading was defined as the presence or absence of a solid growth pattern. RESULTS: Median follow-up was 60 months. 5-Year local control (LC), overall survival (OS) and distant metastasis free survival (DMFS) of all patients were 68.6%, 74.8% and 65.7%, respectively. On multivariate analysis, the prescribed dose (p=0.001) and gross tumor volume (p=0.002) were significant independent risk factors for LC. No significant difference for local control of solid/non-solid growth patterns was found (p=0.093). Solid growth pattern was an independent risk factor for both OS (p=0.033) and DMFS (p=0.024). CONCLUSIONS: CIRT appears able to locally control solid growth pattern ACC in the head and neck. Improved intervention is needed to extend DMFS and OS.
Authors: Philipp Wolber; Lisa Nachtsheim; Franziska Hoffmann; Jens Peter Klußmann; Moritz Meyer; Ferdinand von Eggeling; Orlando Guntinas-Lichius; Alexander Quaas; Christoph Arolt Journal: Head Neck Pathol Date: 2021-04-22
Authors: Kristin Lang; Sebastian Adeberg; Semi Harrabi; Thomas Held; Meinhard Kieser; Jürgen Debus; Klaus Herfarth Journal: BMC Cancer Date: 2021-07-15 Impact factor: 4.430