Literature DB >> 2852821

Low permeability of the blood-brain barrier to nanomolar concentrations of immunoreactive alpha-melanotropin.

J F Wilson1.   

Abstract

The permeability of the blood-brain barrier (BBB) to immunoreactive alpha-melanotropin (alpha-MSH) was quantified in rats pretreated with monosodium L-glutamic acid to deplete their CNS stores of endogenous alpha-MSH. The methodology, suitable for poorly permeable substances, monitored blood and brain tissue concentrations of alpha-MSH over 15 min following intravenous injection of 30 nmol synthetic alpha-MSH. Rate constants for entry of alpha-MSH into brain tissue were estimated from separate non-linear least-squares fits of connecting two- and one-compartment open models to plasma and extravascular brain tissue concentration data, respectively. Comparisons were made to rate constants measured similarly for 14C-inulin. The BBB had a low permeability to immunoreactive alpha-MSH, consistent with peptide penetrating the barrier by passive diffusion dependent upon the lipid solubility of the molecule.

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Year:  1988        PMID： 2852821     DOI： 10.1007/bf00177572

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  21 in total

1.  Radioautographic localization of radioactivity in rat brain after intracarotid injection of 125I-alpha-melanocyte-stimulating hormone.

Authors:  G Pelletier; F Labrie; A J Kastin; A V Schally
Journal:  Pharmacol Biochem Behav       Date:  1975 Jul-Aug       Impact factor: 3.533

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Journal:  Life Sci       Date:  1979-07-30       Impact factor: 5.037

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Journal:  Science       Date:  1969-05-09       Impact factor: 47.728

Review 4.  The opiomelanotropinergic neuronal and endocrine systems.

Authors:  T L O'Donohue; D M Dorsa
Journal:  Peptides       Date:  1982 May-Jun       Impact factor: 3.750

5.  Quantification of the permeability of the blood-CSF barrier to alpha-MSH in the rat.

Authors:  J F Wilson; S Anderson; G Snook; K D Llewellyn
Journal:  Peptides       Date:  1984 Jul-Aug       Impact factor: 3.750

6.  Entry of opioid peptides into the central nervous system.

Authors:  S I Rapoport; W A Klee; K D Pettigrew; K Ohno
Journal:  Science       Date:  1980-01-04       Impact factor: 47.728

7.  Theoretical interpretation of extraction (in brain) of peptides including concentration variations.

Authors:  R R Sharma; R L Vimal
Journal:  Brain Res       Date:  1984-08-13       Impact factor: 3.252

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Journal:  Brain Res Bull       Date:  1976 Jan-Feb       Impact factor: 4.077

9.  Relationships between alpha-MSH levels in blood and in cerebrospinal fluid.

Authors:  A A De Rotte; H J Bouman; T B van Wimersma Greidanus
Journal:  Brain Res Bull       Date:  1980 Jul-Aug       Impact factor: 4.077

10.  Peptides and the blood-brain barrier: lipophilicity as a predictor of permeability.

Authors:  W A Banks; A J Kastin
Journal:  Brain Res Bull       Date:  1985-09       Impact factor: 4.077
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  12 in total

Review 1.  Small molecular drug transfer across the blood-brain barrier via carrier-mediated transport systems.

Authors:  Akira Tsuji
Journal:  NeuroRx       Date:  2005-01

Review 2.  Delivering peptides to the central nervous system: dilemmas and strategies.

Authors:  W A Banks; A J Kastin; C M Barrera
Journal:  Pharm Res       Date:  1991-11       Impact factor: 4.200

Review 3.  Blood-brain barrier and feeding: regulatory roles of saturable transport systems for ingestive peptides.

Authors:  Abba J Kastin; Weihong Pan
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Authors:  N Rajora; G Boccoli; D Burns; S Sharma; A P Catania; J M Lipton
Journal:  J Neurosci       Date:  1997-03-15       Impact factor: 6.167

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Authors:  J B van Bree; S Tio; A G de Boer; M Danhof; J C Verhoef; D D Breimer
Journal:  Pharm Res       Date:  1990-03       Impact factor: 4.200

6.  Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage.

Authors:  D Giuliani; C Mioni; C Bazzani; D Zaffe; A R Botticelli; S Capolongo; A Sabba; M Galantucci; A Iannone; P Grieco; E Novellino; G Colombo; A Tomasi; A Catania; S Guarini
Journal:  Br J Pharmacol       Date:  2007-01-22       Impact factor: 8.739

Review 7.  Cerebrovascular permeability to peptides: manipulations of transport systems at the blood-brain barrier.

Authors:  B V Zlokovic
Journal:  Pharm Res       Date:  1995-10       Impact factor: 4.200

8.  Antipyretic role of endogenous melanocortins mediated by central melanocortin receptors during endotoxin-induced fever.

Authors:  Q H Huang; M L Entwistle; J D Alvaro; R S Duman; V J Hruby; J B Tatro
Journal:  J Neurosci       Date:  1997-05-01       Impact factor: 6.167

9.  αMSH blunts endotoxin-induced MuRF1 and atrogin-1 upregulation in skeletal muscle by modulating NF-κB and Akt/FoxO1 pathway.

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Journal:  Mediators Inflamm       Date:  2014-09-09       Impact factor: 4.711

10.  Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models.

Authors:  Hai Zhang; Chenguang Wu; Qiaofen Chen; Xiaoluo Chen; Zhigang Xu; Jing Wu; Dongsheng Cai
Journal:  PLoS One       Date:  2013-05-20       Impact factor: 3.240
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