Anika Tandon1, Caroline Watson2, Ramesh Ayyala3. 1. Pediatric Eye Associates, Tulsa, Oklahoma. 2. University of Alabama School of Medicine, University of Alabama, Birmingham, Alabama. 3. Department of Ophthalmology, Tulane University, New Orleans, Louisiana. Electronic address: rayyala@tulane.edu.
Abstract
PURPOSE: To compare the diameter of Schlemm's canal in children with and without congenital glaucoma as measured in vivo by means of ultrasound biomicroscopy. METHODS: In this prospective single-center study of pediatric subjects (<18 years of age) the diameter of Schlemm's canal in nonglaucomatous and glaucomatous eyes was compared. An 80 MHz iUltrasound probe (iScience Interventional Inc, Menlo Park, CA) placed near the limbus was used to identify and measure the canal's diameter with special attention to the anterior segment anatomy (especially in subjects with congenital glaucoma). RESULTS: A total of 20 subjects were included; mean age of subjects without glaucoma was 6.6 ± 6.65 years; of those with glaucoma, 9.4 ± 11.80 months. The mean canal diameter in nonglaucomatous eyes was 142 ± 33.2 μm (range, 90-196 μm); in glaucomatous eyes, 64.9 ± 10.90 μm (P = 0.007). Schlemm's canal could not be identified in 50% of patients with congenital glaucoma. There was a trend toward smaller canal diameter in subjects with no glaucoma <2 years old. Mean canal diameter in nonglaucomatous eyes was 103 ± 8 μm (range, 90-115 μm) in subjects <2 years of age and 161 ± 20 μm (range, 110-196 μm) in subjects >2 years of age (P = 0.0012). CONCLUSIONS: In our pediatric study cohort the diameter of Schlemm's canal varied by age and presence of glaucoma.
PURPOSE: To compare the diameter of Schlemm's canal in children with and without congenital glaucoma as measured in vivo by means of ultrasound biomicroscopy. METHODS: In this prospective single-center study of pediatric subjects (<18 years of age) the diameter of Schlemm's canal in nonglaucomatous and glaucomatous eyes was compared. An 80 MHz iUltrasound probe (iScience Interventional Inc, Menlo Park, CA) placed near the limbus was used to identify and measure the canal's diameter with special attention to the anterior segment anatomy (especially in subjects with congenital glaucoma). RESULTS: A total of 20 subjects were included; mean age of subjects without glaucoma was 6.6 ± 6.65 years; of those with glaucoma, 9.4 ± 11.80 months. The mean canal diameter in nonglaucomatous eyes was 142 ± 33.2 μm (range, 90-196 μm); in glaucomatous eyes, 64.9 ± 10.90 μm (P = 0.007). Schlemm's canal could not be identified in 50% of patients with congenital glaucoma. There was a trend toward smaller canal diameter in subjects with no glaucoma <2 years old. Mean canal diameter in nonglaucomatous eyes was 103 ± 8 μm (range, 90-115 μm) in subjects <2 years of age and 161 ± 20 μm (range, 110-196 μm) in subjects >2 years of age (P = 0.0012). CONCLUSIONS: In our pediatric study cohort the diameter of Schlemm's canal varied by age and presence of glaucoma.
Authors: Christopher Le; Mariana Baroni; Alfred Vinnett; Moran R Levin; Camilo Martinez; Mohamad Jaafar; William P Madigan; Janet L Alexander Journal: Transl Vis Sci Technol Date: 2020-12-23 Impact factor: 3.283