Ajay Gopalakrishna1, Thomas A Longo1, Joseph J Fantony1, Michael R Harrison2, Brant A Inman3. 1. Division of Urology, Duke University Medical Center, Durham, NC. 2. Medical Oncology, Duke University Medical Center, Durham, NC. 3. Division of Urology, Duke University Medical Center, Durham, NC. Electronic address: brant.inman@duke.edu.
Abstract
INTRODUCTION: Physical activity has been shown to significantly improve health-related quality of life (HRQOL) and survivorship in a variety of patients with cancer . However, little is known about the physical activity patterns of bladder cancer survivors and how these are related to HRQOL in the United States. Our objective was to describe self-reported physical activity patterns and HRQOL and examine the association between these measures in a large cohort of bladder cancer survivors. MATERIAL AND METHODS: In this cross-sectional study, long-term bladder cancer survivors identified through an institutional database were mailed a survey that included the Functional Assessment of Cancer Therapy Bladder Cancer (FACT-BL) and the International Physical Activity Questionnaire (IPAQ). Associations between HRQOL, as assessed by the FACT-BL, and physical activity, as assessed by the IPAQ, were examined by stratified analyses of HRQOL by different levels of physical activity, proportional odds ordinal logistic regression models, and local polynomial regression models. RESULTS: A total of 472 subjects (49% response rate) completed the survey. The mean age was 74 years; 81% were male and 87% were white. The median total weekly physical activity was 2,794 MET-min. Subjects reporting "high" physical activity had a median FACT-BL score of 129 compared with 119 among those reporting "low" physical activity, a statistically and clinically significant difference. Similarly, subjects reporting "high" physical activity had a 2.2-fold increased odds of reporting higher global HRQOL compared with subjects reporting "low" physical activity. CONCLUSIONS: This large cohort of bladder cancer survivors reported high levels of physical activity. Physical activity was positively associated with HRQOL. Further studies investigating the causal relationship between physical activity and HRQOL in the posttreatment setting in bladder cancer survivors are warranted.
INTRODUCTION: Physical activity has been shown to significantly improve health-related quality of life (HRQOL) and survivorship in a variety of patients with cancer . However, little is known about the physical activity patterns of bladder cancer survivors and how these are related to HRQOL in the United States. Our objective was to describe self-reported physical activity patterns and HRQOL and examine the association between these measures in a large cohort of bladder cancer survivors. MATERIAL AND METHODS: In this cross-sectional study, long-term bladder cancer survivors identified through an institutional database were mailed a survey that included the Functional Assessment of Cancer Therapy Bladder Cancer (FACT-BL) and the International Physical Activity Questionnaire (IPAQ). Associations between HRQOL, as assessed by the FACT-BL, and physical activity, as assessed by the IPAQ, were examined by stratified analyses of HRQOL by different levels of physical activity, proportional odds ordinal logistic regression models, and local polynomial regression models. RESULTS: A total of 472 subjects (49% response rate) completed the survey. The mean age was 74 years; 81% were male and 87% were white. The median total weekly physical activity was 2,794 MET-min. Subjects reporting "high" physical activity had a median FACT-BL score of 129 compared with 119 among those reporting "low" physical activity, a statistically and clinically significant difference. Similarly, subjects reporting "high" physical activity had a 2.2-fold increased odds of reporting higher global HRQOL compared with subjects reporting "low" physical activity. CONCLUSIONS: This large cohort of bladder cancer survivors reported high levels of physical activity. Physical activity was positively associated with HRQOL. Further studies investigating the causal relationship between physical activity and HRQOL in the posttreatment setting in bladder cancer survivors are warranted.
Authors: Mireille N M van Poppel; Mai J M Chinapaw; Lidwine B Mokkink; Willem van Mechelen; Caroline B Terwee Journal: Sports Med Date: 2010-07-01 Impact factor: 11.136
Authors: Daniel Santa Mina; Crissa L Guglietti; Shabbir M H Alibhai; Andrew G Matthew; Robin Kalnin; Nora Ahmad; Uri Lindner; John Trachtenberg Journal: J Cancer Surviv Date: 2013-12-07 Impact factor: 4.442
Authors: Lawrence H Kushi; Colleen Doyle; Marji McCullough; Cheryl L Rock; Wendy Demark-Wahnefried; Elisa V Bandera; Susan Gapstur; Alpa V Patel; Kimberly Andrews; Ted Gansler Journal: CA Cancer J Clin Date: 2012 Jan-Feb Impact factor: 508.702
Authors: David Cella; David T Eton; Diane L Fairclough; Philip Bonomi; Anne E Heyes; Cheryl Silberman; Michael K Wolf; David H Johnson Journal: J Clin Epidemiol Date: 2002-03 Impact factor: 6.437
Authors: D F Cella; D S Tulsky; G Gray; B Sarafian; E Linn; A Bonomi; M Silberman; S B Yellen; P Winicour; J Brannon Journal: J Clin Oncol Date: 1993-03 Impact factor: 44.544
Authors: Yingqi Wang; Andrew Chang; Wei Phin Tan; Joseph J Fantony; Ajay Gopalakrishna; Gregory J Barton; Paul E Wischmeyer; Rajan T Gupta; Brant A Inman Journal: Eur Urol Oncol Date: 2019-05-25
Authors: Arnold Degboe; Cristina Ivanescu; Jeffrey M Rohay; Ralph R Turner; David Cella Journal: Support Care Cancer Date: 2019-03-01 Impact factor: 3.603