Literature DB >> 2852717

Syphilis evaluation and therapy: a study of current practices in a university hospital.

C Whiteside1, F T Fitzgerald.   

Abstract

The incidence of syphilis, after declining for several years, increased by 23% in the first quarter of 1987. The authors reviewed the charts of 100 patients with syphilis in order to determine how such patients were managed in a university setting. Although 77 patients met Centers for Disease Control (CDC) indications for lumbar puncture, only 11 patients had the procedure. Most patients for whom treatment was indicated either were not treated or were treated with inadequate or incorrect medications. Only 30 patients received follow-up serologic tests, and of these, only one received follow-up at the intervals recommended by the CDC. This study indicates that physicians may either be unfamiliar or disagree with the current CDC guidelines for evaluation and management of patients with syphilis. Physicians should know these guidelines and document their reasoning if they choose not to follow them. Long-term follow-up of patients with syphilis is important to ensure effective treatment and to increase understanding of this disease.

Entities:  

Mesh:

Year:  1988        PMID: 2852717     DOI: 10.1007/bf02596097

Source DB:  PubMed          Journal:  J Gen Intern Med        ISSN: 0884-8734            Impact factor:   5.128


  18 in total

1.  THE TUSKEGEE STUDY OF UNTREATED SYPHILIS; THE 30TH YEAR OF OBSERVATION.

Authors:  D H ROCKWELL; A R YOBS; M B MOORE
Journal:  Arch Intern Med       Date:  1964-12

2.  The effect of the method of administration on the therapeutic efficacy of sodium penicillin in experimental syphilis.

Authors:  H EAGLE; H J MAGNUSON; R FLEISCHMAN
Journal:  Bull Johns Hopkins Hosp       Date:  1946-08

3.  Persistence of neurosyphilis despite multiple treatment regimens.

Authors:  C M Whiteside
Journal:  Am J Med       Date:  1989-08       Impact factor: 4.965

4.  Neurologic relapse after benzathine penicillin therapy for secondary syphilis in a patient with HIV infection.

Authors:  C D Berry; T M Hooton; A C Collier; S A Lukehart
Journal:  N Engl J Med       Date:  1987-06-18       Impact factor: 91.245

Review 5.  Penicillin in the treatment of syphilis. The experience of three decades.

Authors:  O Idsoe; T Guthe; R R Willcox
Journal:  Bull World Health Organ       Date:  1972       Impact factor: 9.408

6.  Inappropriate use of the cerebrospinal fluid Venereal Disease Research Laboratory (VDRL) test to exclude neurosyphilis.

Authors:  P E Dans; L Cafferty; S E Otter; R J Johnson
Journal:  Ann Intern Med       Date:  1986-01       Impact factor: 25.391

7.  Lumbar puncture in asymptomatic late syphilis. An analysis of the benefits and risks.

Authors:  J Wiesel; D N Rose; A L Silver; H S Sacks; R H Bernstein
Journal:  Arch Intern Med       Date:  1985-03

8.  Neurosyphilis: an update.

Authors:  R P Simon
Journal:  West J Med       Date:  1981-01

9.  Neurosyphilis and penicillin levels in cerebrospinal fluid.

Authors:  J A Mohr; W Griffiths; R Jackson; H Saadah; P Bird; J Riddle
Journal:  JAMA       Date:  1976-11-08       Impact factor: 56.272

10.  Alteration in the natural history of neurosyphilis by concurrent infection with the human immunodeficiency virus.

Authors:  D R Johns; M Tierney; D Felsenstein
Journal:  N Engl J Med       Date:  1987-06-18       Impact factor: 91.245

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