Hoang Kim Tu Trinh1, Duy Le Pham1,2, Su-Chin Kim3, Ri-Yeon Kim2, Hae-Sim Park1,2, Seung-Hyun Kim4,5. 1. Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea. 2. Department of Biomedical Sciences, Ajou University School of Medicine, Suwon, South Korea. 3. Clinical Trial Center, Ajou University Medical Center, Suwon, South Korea. 4. Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea. kimsh@ajou.ac.kr. 5. Clinical Trial Center, Ajou University Medical Center, Suwon, South Korea. kimsh@ajou.ac.kr.
Abstract
BACKGROUND: MicroRNAs (miRNAs) modulate expressions of inflammatory genes, thereby regulating inflammatory responses. Single nucleotide polymorphisms (SNPs) in miRNAs could affect their efficiency in binding to messenger RNAs (mRNAs). OBJECTIVE: We investigated the associations of miRNA SNPs with asthma phenotypes. miR-196a2 (rs11614913 T>C), miR-146a (rs2910164 C>G), and miR-499 (rs3746444 A>G) were genotyped in 347 asthma patients and 172 normal healthy controls (NCs). RESULTS: The CT/CC genotype of miR-196a2 rs11614913 was associated with eosinophilic asthma (p = 0.004) and a higher sputum eosinophil count compared with the TT genotype (p = 0.003). The CG/GG genotype of miR-146a rs2910164 tended to be associated with higher bronchial hyperresponsiveness to methacholine (PC20) compared with the CC genotype. The AG/GG genotype of miR-499 rs3746444 was associated with higher predicted values of forced expiratory volume in 1 s (%FEV1) compared with the AA genotype (p = 0.008). CONCLUSIONS: Genetic polymorphisms in miR-196a2, miR-146a, and miR-499 could be potential biomarkers for asthma phenotypes and targets for asthma treatments in a Korean population.
BACKGROUND: MicroRNAs (miRNAs) modulate expressions of inflammatory genes, thereby regulating inflammatory responses. Single nucleotide polymorphisms (SNPs) in miRNAs could affect their efficiency in binding to messenger RNAs (mRNAs). OBJECTIVE: We investigated the associations of miRNA SNPs with asthma phenotypes. miR-196a2 (rs11614913 T>C), miR-146a (rs2910164 C>G), and miR-499 (rs3746444 A>G) were genotyped in 347 asthmapatients and 172 normal healthy controls (NCs). RESULTS: The CT/CC genotype of miR-196a2rs11614913 was associated with eosinophilic asthma (p = 0.004) and a higher sputum eosinophil count compared with the TT genotype (p = 0.003). The CG/GG genotype of miR-146ars2910164 tended to be associated with higher bronchial hyperresponsiveness to methacholine (PC20) compared with the CC genotype. The AG/GG genotype of miR-499rs3746444 was associated with higher predicted values of forced expiratory volume in 1 s (%FEV1) compared with the AA genotype (p = 0.008). CONCLUSIONS: Genetic polymorphisms in miR-196a2, miR-146a, and miR-499 could be potential biomarkers for asthma phenotypes and targets for asthma treatments in a Korean population.
Entities:
Keywords:
Airway Hyperresponsiveness; Airway Smooth Muscle; Asthma; Chronic Obstructive Pulmonary Disease; Normal Control Group
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