Literature DB >> 28526740

Midostaurin Gets FDA Nod for AML.

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Abstract

The FDA has approved the small-molecule inhibitor midostaurin in combination with chemotherapy to treat acute myeloid leukemia. It is the first approved drug for the disease that specifically targets FLT3 mutations, which occur in about a quarter of all AML cases and are associated with particularly poor outcomes. ©2017 American Association for Cancer Research.

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Year:  2017        PMID: 28526740     DOI: 10.1158/2159-8290.CD-NB2017-072

Source DB:  PubMed          Journal:  Cancer Discov        ISSN: 2159-8274            Impact factor:   39.397


  3 in total

1.  Nuclear membrane-localised NOX4D generates pro-survival ROS in FLT3-ITD-expressing AML.

Authors:  Jennifer N Moloney; Ashok Kumar Jayavelu; Joanna Stanicka; Sarah L Roche; Rebecca L O'Brien; Sebastian Scholl; Frank-D Böhmer; Thomas G Cotter
Journal:  Oncotarget       Date:  2017-11-01

2.  Cost-effectiveness analysis for midostaurin versus standard of care in acute myeloid leukemia in the United Kingdom.

Authors:  Gabriel Tremblay; Mike Dolph; Sachin Patel; Patricia Brandt; Anna Forsythe
Journal:  Cost Eff Resour Alloc       Date:  2018-10-04

3.  Improving awareness of several combination therapies for acute myeloid leukemia among oncology and hematology team members in Colorado, USA.

Authors:  Rovshan M Ismailov; Dyana T Saenz; Pere Gascon; Marcio Nucci; Zaytuna D Khasanova
Journal:  Hematol Transfus Cell Ther       Date:  2021-02-12
  3 in total

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