Literature DB >> 2852661

Quantitative receptor autoradiography in the human brain. Methodical aspects.

K Zilles1, A Schleicher, M Rath, A Bauer.   

Abstract

Quantitative receptor autoradiography on sections of the human brain raises methodical problems of which some are relevant also for studies in animal tissue, but others are unique in studies of human brain tissue. Procedures for the following methodical aspects are discussed: image analysis for quantitation of the regional distribution of receptor densities, saturation analysis on autoradiographs, influence of age and post-mortem delay and quenching of beta-radiation in brain tissue. The solutions proposed to these problems make receptor autoradiography in the human brain to a reliable method for studies of chemical neuroanatomy.

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Year:  1988        PMID： 2852661     DOI： 10.1007/bf00500977

Source DB:  PubMed          Journal:  Histochemistry        ISSN： 0301-5564


  27 in total

Review 1.  Membrane receptors and hormone action.

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Journal:  Adv Protein Chem       Date:  1976

2.  Characterization and localization of serotonin receptors in human brain postmortem.

Authors:  A Biegon; S Kargman; L Snyder; B S McEwen
Journal:  Brain Res       Date:  1986-01-15       Impact factor: 3.252

3.  Localization of serotonin 5-HT2 receptors in living human brain by positron emission tomography using N1-([11C]-methyl)-2-Br-LSD.

Authors:  D F Wong; J R Lever; P R Hartig; R F Dannals; V Villemagne; B J Hoffman; A A Wilson; H T Ravert; J M Links; U Scheffel
Journal:  Synapse       Date:  1987       Impact factor: 2.562

4.  Postmortem changes in rat brain: studies on membrane-bound enzymes and receptors.

Authors:  P J Syapin; T Ritchie; L Noble; E P Noble
Journal:  J Neurochem       Date:  1987-04       Impact factor: 5.372

5.  Regional tritium quenching in quantitative autoradiography of the central nervous system.

Authors:  W A Geary; G F Wooten
Journal:  Brain Res       Date:  1985-06-17       Impact factor: 3.252

6.  5-Hydroxytryptamine-sensitive [3H]imipramine binding of protein nature in the human brain. II. Effect of normal aging and dementia disorders.

Authors:  J O Marcusson; I Alafuzoff; I T Bäckström; E Ericson; C G Gottfries; B Winblad
Journal:  Brain Res       Date:  1987-11-03       Impact factor: 3.252

7.  Effects of postmortem delay and temperature on neurotransmitter receptor binding in a rat model of the human autopsy process.

Authors:  P J Whitehouse; D Lynch; M J Kuhar
Journal:  J Neurochem       Date:  1984-08       Impact factor: 5.372

8.  Binding of the novel serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin in normal and Alzheimer brain.

Authors:  D N Middlemiss; A M Palmer; N Edel; D M Bowen
Journal:  J Neurochem       Date:  1986-03       Impact factor: 5.372

9.  Direct autoradiographic determination of M1 and M2 muscarinic acetylcholine receptor distribution in the rat brain: relation to cholinergic nuclei and projections.

Authors:  D G Spencer; E Horváth; J Traber
Journal:  Brain Res       Date:  1986-08-13       Impact factor: 3.252

10.  Density and distribution of NMDA receptors in the human hippocampus in Alzheimer's disease.

Authors:  J W Geddes; H Chang-Chui; S M Cooper; I T Lott; C W Cotman
Journal:  Brain Res       Date:  1986-12-03       Impact factor: 3.252
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  7 in total

Review 1.  Immunohistochemistry of cholinergic receptors.

Authors:  H Schröder
Journal:  Anat Embryol (Berl)       Date:  1992-10

2.  A new method for quenching correction leads to revisions of data in receptor autoradiography.

Authors:  K Zilles; K zur Nieden; A Schleicher; J Traber
Journal:  Histochemistry       Date:  1990

3.  Laminar distribution of the multiple opioid receptors in the human cerebral cortex.

Authors:  J M Hiller; L Q Fan
Journal:  Neurochem Res       Date:  1996-11       Impact factor: 3.996

4.  Mapping of human and macaque sensorimotor areas by integrating architectonic, transmitter receptor, MRI and PET data.

Authors:  K Zilles; G Schlaug; M Matelli; G Luppino; A Schleicher; M Qü; A Dabringhaus; R Seitz; P E Roland
Journal:  J Anat       Date:  1995-12       Impact factor: 2.610

5.  Parcellation of the frontal cortex of the New World monkey Callithrix jacchus by eight neurotransmitter-binding sites.

Authors:  R Gebhard; K Zilles; A Schleicher; B J Everitt; T W Robbins; I Divac
Journal:  Anat Embryol (Berl)       Date:  1995-06

6.  Quantitative receptor autoradiography of eight different transmitter-binding sites in the hippocampus of the common marmoset, Callithrix jacchus.

Authors:  M Kraemer; K Zilles; A Schleicher; R Gebhard; T W Robbins; B J Everitt; I Divac
Journal:  Anat Embryol (Berl)       Date:  1995-03

7.  Distribution of the Noradrenaline Innervation and Adrenoceptors in the Macaque Monkey Thalamus.

Authors:  Isabel Pérez-Santos; Nicola Palomero-Gallagher; Karl Zilles; Carmen Cavada
Journal:  Cereb Cortex       Date:  2021-07-29       Impact factor: 5.357
  7 in total

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