David Weakley1, George Cotsonis2, M Edward Wilson3, David A Plager4, Edward G Buckley5, Scott R Lambert6. 1. Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address: David.Weakley@Childrens.com. 2. Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia. 3. Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina. 4. Department of Ophthalmology, Indiana University, Indianapolis, Indiana. 5. Duke University, Durham, North Carolina. 6. Department of Ophthalmology, Stanford University School of Medicine, Stanford, California.
Abstract
PURPOSE: To report the prevalence of anisometropia at age 5 years after unilateral intraocular lens (IOL) implantation in infants. DESIGN: Prospective randomized clinical trial. METHODS:Fifty-seven infants in the Infant Aphakia Treatment Study (IATS) with a unilateral cataract were randomized to IOL implantation with an initial targeted postoperative refractive error of either +8 diopters (D) (infants 28 to <48 days of age) or +6 D (infants 48-210 days of age). Anisometropia was calculated at age 5 years. Six patients were excluded from the analyses. RESULTS: Median age at cataract surgery was 2.2 months (interquartile range [IQR], 1.2, 3.5 months). The mean age at the age 5 years follow-up visit was 5.0 ± 0.1 years (range, 4.9-5.4 years). The median refractive error at the age 5 years visit of the treated eyes was -2.25 D (IQR -5.13, +0.88 D) and of the fellow eyes +1.50 D (IQR +0.88, +2.25). Median anisometropia was -3.50 D (IQR -8.25, -0.88 D); range -19.63 to +2.75 D. Patients with glaucoma in the treated eye (n = 9) had greater anisometropia (glaucoma, median -8.25 D; IQR -11.38, -5.25 D vs no glaucoma median -2.75; IQR -6.38, -0.75 D; P = .005). CONCLUSIONS: The majority of pseudophakic eyes had significant anisometropia at age 5 years. Anisometropia was greater in patients that developed glaucoma. Variability in eye growth and myopic shift continue to make refractive outcomes challenging for IOL implantation during infancy.
RCT Entities:
PURPOSE: To report the prevalence of anisometropia at age 5 years after unilateral intraocular lens (IOL) implantation in infants. DESIGN: Prospective randomized clinical trial. METHODS: Fifty-seven infants in the InfantAphakia Treatment Study (IATS) with a unilateral cataract were randomized to IOL implantation with an initial targeted postoperative refractive error of either +8 diopters (D) (infants 28 to <48 days of age) or +6 D (infants 48-210 days of age). Anisometropia was calculated at age 5 years. Six patients were excluded from the analyses. RESULTS: Median age at cataract surgery was 2.2 months (interquartile range [IQR], 1.2, 3.5 months). The mean age at the age 5 years follow-up visit was 5.0 ± 0.1 years (range, 4.9-5.4 years). The median refractive error at the age 5 years visit of the treated eyes was -2.25 D (IQR -5.13, +0.88 D) and of the fellow eyes +1.50 D (IQR +0.88, +2.25). Median anisometropia was -3.50 D (IQR -8.25, -0.88 D); range -19.63 to +2.75 D. Patients with glaucoma in the treated eye (n = 9) had greater anisometropia (glaucoma, median -8.25 D; IQR -11.38, -5.25 D vs no glaucoma median -2.75; IQR -6.38, -0.75 D; P = .005). CONCLUSIONS: The majority of pseudophakic eyes had significant anisometropia at age 5 years. Anisometropia was greater in patients that developed glaucoma. Variability in eye growth and myopic shift continue to make refractive outcomes challenging for IOL implantation during infancy.
Authors: M Edward Wilson; Rupal H Trivedi; David R Weakley; George A Cotsonis; Scott R Lambert Journal: Ophthalmology Date: 2017-02-10 Impact factor: 12.079
Authors: David R Weakley; Michael J Lynn; Lindreth Dubois; George Cotsonis; M Edward Wilson; Edward G Buckley; David A Plager; Scott R Lambert Journal: Ophthalmology Date: 2017-02-16 Impact factor: 12.079
Authors: Sharon F Freedman; Michael J Lynn; Allen D Beck; Erick D Bothun; Faruk H Örge; Scott R Lambert Journal: JAMA Ophthalmol Date: 2015-08 Impact factor: 7.389
Authors: S K McClatchey; E Dahan; E Maselli; H V Gimbel; M E Wilson; S R Lambert; E G Buckley; S F Freedman; D A Plager; M M Parks Journal: Ophthalmology Date: 2000-01 Impact factor: 12.079
Authors: David R Weakley; Azhar Nizam; Deborah K VanderVeen; M Edward Wilson; Stacy Kruger; Scott R Lambert Journal: Ophthalmology Date: 2022-04-08 Impact factor: 14.277
Authors: David R Weakley; Michael J Lynn; Lindreth Dubois; George Cotsonis; M Edward Wilson; Edward G Buckley; David A Plager; Scott R Lambert Journal: Ophthalmology Date: 2018-10 Impact factor: 14.277