| Literature DB >> 2852624 |
G Czapski1, S Goldstein, D Meyerstein.
Abstract
Usually the toxicity of superoxide is attributed to its ability to reduce metal ions and subsequently reoxidation of the metal by hydrogen peroxide yields deleterious oxidizing species. As many other nontoxic biological reductants reduce metal compounds, we suggest that part of the mechanism of superoxide toxicity results from its ability to oxidize metal ions bound to biological targets, which subsequently degrade the target via an intramolecular electron transfer reaction.Entities:
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Year: 1988 PMID： 2852624 DOI： 10.3109/10715768809055147
Source DB: PubMed Journal: Free Radic Res Commun ISSN： 8755-0199