Sasha Bernatsky1, Audrey Smargiassi2, Lawrence Joseph3, Phillip Awadalla4, Ines Colmegna5, Marie Hudson6, Marvin J Fritzler7. 1. Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, 687 Pine Avenue West, V-Building (V2.09), Montreal, Canada H3A 1A1. Electronic address: sasha.bernatsky@mcgill.ca. 2. Département de santé environnementale et de santé au travail, Université de Montréal, Pavillon Marguerite d'Youville, École de santé publique, Montréal, QC, Canada; Institut National de Santé Publique du Québec, Montréal, QC, Canada. 3. Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, 687 Pine Avenue West, V-Building (V2.09), Montreal, Canada H3A 1A1. 4. Ontario Institute of Cancer Research, Unviersity of Toronto, ON, Canada. 5. Research Institute of McGill University Health Centre, Montreal, QC, Canada. 6. Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, 687 Pine Avenue West, V-Building (V2.09), Montreal, Canada H3A 1A1; Jewish General Hospital and Lady Davis Institute for medical research, Montréal, Canada. 7. Unviersity of Calgary, Calgary, AB, Canada.
Abstract
OBJECTIVE: To determine the association of anti-citrullinated antibodies (ACPA) with the ambient air pollutants fine particulate matter (PM2.5) and sulfur dioxide (SO2). METHODS: The CARTaGENE first-wave cohort includes 20,000 general population subjects from Quebec (Canada). On a sample of unselected 1586 subjects, we determined serum, ACPA and performed multivariable logistic regression, for the outcome of positive ACPA, assessing for independent effects of our air pollution variables, adjusting for age, sex, smoking, and French Canadian origin. Two models assessed distance to main industrial emitters of PM2.5, and of SO2, and two models assessed tons of SO2 and of PM2.5 annual emissions. We also assessed associations with PM2.5 regional ambient concentrations estimated with satellite imagery. RESULTS: Adjusted analyses suggested a positive association between annual industrial PM2.5 and SO2 emissions and the presence of ACPA antibodies (OR: 1.02, 95%CI 1.00-1.04 per 10t of PM2.5 and 100t of SO2). The data were also consistent with a negative association between the presence of ACPA, and distance to a major industrial emitter of both PM2.5 and SO2. We found no association with PM2.5 estimates of ambient levels. CONCLUSIONS: These analyses suggest that exposure to industrial emissions of air pollutants is related to ACPA positivity.
OBJECTIVE: To determine the association of anti-citrullinated antibodies (ACPA) with the ambient air pollutants fine particulate matter (PM2.5) and sulfur dioxide (SO2). METHODS: The CARTaGENE first-wave cohort includes 20,000 general population subjects from Quebec (Canada). On a sample of unselected 1586 subjects, we determined serum, ACPA and performed multivariable logistic regression, for the outcome of positive ACPA, assessing for independent effects of our air pollution variables, adjusting for age, sex, smoking, and French Canadian origin. Two models assessed distance to main industrial emitters of PM2.5, and of SO2, and two models assessed tons of SO2 and of PM2.5 annual emissions. We also assessed associations with PM2.5 regional ambient concentrations estimated with satellite imagery. RESULTS: Adjusted analyses suggested a positive association between annual industrial PM2.5 and SO2 emissions and the presence of ACPA antibodies (OR: 1.02, 95%CI 1.00-1.04 per 10t of PM2.5 and 100t of SO2). The data were also consistent with a negative association between the presence of ACPA, and distance to a major industrial emitter of both PM2.5 and SO2. We found no association with PM2.5 estimates of ambient levels. CONCLUSIONS: These analyses suggest that exposure to industrial emissions of air pollutants is related to ACPA positivity.
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Authors: Jun Seok Park; Seulggie Choi; Kyuwoong Kim; Jooyoung Chang; Sung Min Kim; Seong Rae Kim; Gyeongsil Lee; Joung Sik Son; Kyae Hyung Kim; Eun Young Lee; Sang Min Park Journal: Rheumatology (Oxford) Date: 2021-11-03 Impact factor: 7.580