Shizuka Koh1, Naoyuki Maeda2, Chikako Ikeda3, Sanae Asonuma2, Mai Ogawa2, Takahiro Hiraoka4, Tetsuro Oshika4, Kohji Nishida2. 1. Department of Innovative Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan 2Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan. 2. Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan. 3. Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan 3Research & Development Division, Rohto, Kyoto, Japan. 4. Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Abstract
Purpose: To investigate the association between visual function and ocular surface regularity in dry eye. Methods: We enrolled 52 eyes of 52 dry eye patients (34 dry eyes with superficial punctate keratopathy [SPK] in the central corneal region [central SPK] and 18 dry eyes without central SPK) and 20 eyes of 20 normal control subjects. All eyes had a best-corrected distance visual acuity better than 20/20. We measured two indices of contrast sensitivity function under photopic conditions: contrast sensitivity and letter contrast sensitivity. The area under the log contrast sensitivity function (AULCSF) was calculated from the obtained contrast sensitivity data. Straylight was quantified using a straylight meter. Results: Dry eyes with central SPK had significantly decreased contrast sensitivity function, including AULCSF and letter contrast sensitivity than those without central SPK and normal eyes (P < 0.05 for each). While the straylight values in both dry eye groups did not differ, straylight values were greater than those in normal eyes (P < 0.05 for both). In dry eye, the AULCSF and letter contrast sensitivity negatively correlated with the central SPK score (R = -0.485, P < 0.001, and R = -0.541, P < 0.001, respectively). Conclusions: In dry eye, reduced contrast sensitivity in part results from central SPK overlying the optical zone and the increased straylight results from tear film instability rather than central SPK.
Purpose: To investigate the association between visual function and ocular surface regularity in dry eye. Methods: We enrolled 52 eyes of 52 dry eyepatients (34 dry eyes with superficial punctate keratopathy [SPK] in the central corneal region [central SPK] and 18 dry eyes without central SPK) and 20 eyes of 20 normal control subjects. All eyes had a best-corrected distance visual acuity better than 20/20. We measured two indices of contrast sensitivity function under photopic conditions: contrast sensitivity and letter contrast sensitivity. The area under the log contrast sensitivity function (AULCSF) was calculated from the obtained contrast sensitivity data. Straylight was quantified using a straylight meter. Results:Dry eyes with central SPK had significantly decreased contrast sensitivity function, including AULCSF and letter contrast sensitivity than those without central SPK and normal eyes (P < 0.05 for each). While the straylight values in both dry eye groups did not differ, straylight values were greater than those in normal eyes (P < 0.05 for both). In dry eye, the AULCSF and letter contrast sensitivity negatively correlated with the central SPK score (R = -0.485, P < 0.001, and R = -0.541, P < 0.001, respectively). Conclusions: In dry eye, reduced contrast sensitivity in part results from central SPK overlying the optical zone and the increased straylight results from tear film instability rather than central SPK.
Authors: Loretta B Szczotka-Flynn; Maureen G Maguire; Gui-Shuang Ying; Meng C Lin; Vatinee Y Bunya; Reza Dana; Penny A Asbell Journal: Optom Vis Sci Date: 2019-06 Impact factor: 1.973
Authors: Abdelrahman M Elhusseiny; Ali A Khalil; Reem H El Sheikh; Mohammad A Bakr; Mohamed Gaber Eissa; Yasmine M El Sayed Journal: Int J Ophthalmol Date: 2019-10-18 Impact factor: 1.779