Literature DB >> 28524163

An evolving function of DNA-containing exosomes in chemotherapy-induced immune response.

Paul Kurywchak1, Raghu Kalluri1.   

Abstract

Chemotherapy is a predominant strategy to treat cancer and is often associated with toxicities like severe diarrhea that puts patients at additional risk and can hinder treatment strategies. Lian et al. recently explored the immune-mediated mechanisms of Irinotecan-induced diarrhea in colorectal cancer and found that double-stranded DNA in small vesicles can launch inflammation pathways in immune cells through the cytosolic DNA sensor AIM2.

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Year:  2017        PMID： 28524163      PMCID： PMC5518880          DOI： 10.1038/cr.2017.74

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  11 in total

1.  Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation.

Authors:  Qiaoshi Lian; Jun Xu; Shanshan Yan; Min Huang; Honghua Ding; Xiaoyu Sun; Aiwei Bi; Jian Ding; Bing Sun; Meiyu Geng
Journal:  Cell Res       Date:  2017-04-14       Impact factor: 25.617

2.  Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer.

Authors:  Christoph Kahlert; Sonia A Melo; Alexei Protopopov; Jiabin Tang; Sahil Seth; Moritz Koch; Jianhua Zhang; Juergen Weitz; Lynda Chin; Andrew Futreal; Raghu Kalluri
Journal:  J Biol Chem       Date:  2014-01-07       Impact factor: 5.157

3.  Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer.

Authors:  Sujuan Yang; Sara P Y Che; Paul Kurywchak; Jena L Tavormina; Liv B Gansmo; Pedro Correa de Sampaio; Michael Tachezy; Maximilian Bockhorn; Florian Gebauer; Amanda R Haltom; Sonia A Melo; Valerie S LeBleu; Raghu Kalluri
Journal:  Cancer Biol Ther       Date:  2017-01-25       Impact factor: 4.742

Review 4.  Characterisation and clinical management of CPT-11 (irinotecan)-induced adverse events: the European perspective.

Authors:  H Bleiberg; E Cvitkovic
Journal:  Eur J Cancer       Date:  1996       Impact factor: 9.162

5.  Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.

Authors:  Hadi Valadi; Karin Ekström; Apostolos Bossios; Margareta Sjöstrand; James J Lee; Jan O Lötvall
Journal:  Nat Cell Biol       Date:  2007-05-07       Impact factor: 28.824

Review 6.  An approach to chemotherapy-associated toxicity.

Authors:  Zhanna Livshits; Rama B Rao; Silas W Smith
Journal:  Emerg Med Clin North Am       Date:  2014-02       Impact factor: 2.264

Review 7.  Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer.

Authors:  L Bracci; G Schiavoni; A Sistigu; F Belardelli
Journal:  Cell Death Differ       Date:  2013-06-21       Impact factor: 15.828

8.  Circulating nucleic acids damage DNA of healthy cells by integrating into their genomes.

Authors:  Indraneel Mittra; Naveen Kumar Khare; Gorantla Venkata Raghuram; Rohan Chaubal; Fatema Khambatti; Deepika Gupta; Ashwini Gaikwad; Preeti Prasannan; Akshita Singh; Aishwarya Iyer; Ankita Singh; Pawan Upadhyay; Naveen Kumar Nair; Pradyumna Kumar Mishra; Amit Dutt
Journal:  J Biosci       Date:  2015-03       Impact factor: 1.826

9.  Tracking of microinjected DNA in live cells reveals the intracellular behavior and elimination of extrachromosomal genetic material.

Authors:  Noriaki Shimizu; Fumie Kamezaki; Shiho Shigematsu
Journal:  Nucleic Acids Res       Date:  2005-11-03       Impact factor: 16.971

Review 10.  Routes and mechanisms of extracellular vesicle uptake.

Authors:  Laura Ann Mulcahy; Ryan Charles Pink; David Raul Francisco Carter
Journal:  J Extracell Vesicles       Date:  2014-08-04
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  5 in total

1.  Screening of Serum Exosomal miRNAs as Diagnostic Biomarkers for Gastric Cancer Using Small RNA Sequencing.

Authors:  Jun-Fu Wang; Yue-Mei Jiang; Wen-Hui Zhan; Shan-Ping Ye; Tai-Yuan Li; Jiang-Nan Zhang
Journal:  J Oncol       Date:  2022-05-04       Impact factor: 4.501

2.  RETRACTED: Exosome-Derived miR-130a Activates Angiogenesis in Gastric Cancer by Targeting C-MYB in Vascular Endothelial Cells

Authors:  Haiou Yang; Haiyang Zhang; Shaohua Ge; Tao Ning; Ming Bai; Jialu Li; Shuang Li; Wu Sun; Ting Deng; Le Zhang; Guoguang Ying; Yi Ba
Journal:  Mol Ther       Date:  2018-08-04       Impact factor: 11.454

3.  Exosomal miR‑663b exposed to TGF‑β1 promotes cervical cancer metastasis and epithelial‑mesenchymal transition by targeting MGAT3.

Authors:  Xuewu You; Ying Wang; Jinyu Meng; Sai Han; Lu Liu; Yu Sun; Junhua Zhang; Shuqin Sun; Xinyue Li; Wenxiong Sun; Yajie Dong; Youzhong Zhang
Journal:  Oncol Rep       Date:  2021-03-02       Impact factor: 3.906

Review 4.  DNA in extracellular vesicles: biological and clinical aspects.

Authors:  Julia Elzanowska; Christine Semira; Bruno Costa-Silva
Journal:  Mol Oncol       Date:  2020-08-19       Impact factor: 6.603

5.  Gastric cancer-secreted exosomal X26nt increases angiogenesis and vascular permeability by targeting VE-cadherin.

Authors:  Xiaocui Chen; Shuqiong Zhang; Kun Du; Naisheng Zheng; Yi Liu; Hui Chen; Guohua Xie; Yanhui Ma; Yunlan Zhou; Yingxia Zheng; Lingfang Zeng; Junyao Yang; Lisong Shen
Journal:  Cancer Sci       Date:  2021-03-10       Impact factor: 6.518
  5 in total

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