N I Kurysheva1, E V Maslova1, A V Trubilina1, T D Ardzhevnishvili1, A V Fomin2. 1. Consultative and Diagnostic Department of the Ophthalmology Center of the Federal Medical and Biological Agency of Russia, A.I. Burnazyan Federal Medical Biophysical Center of FMBA, Institute of Improvement of Professional Skill of the FMBA of Russia, 15 Gamalei St., Moscow, Russian Federation, 123098. 2. Research Institute of Eye Diseases, 11 A, B, Rossolimo St., Moscow, Russian Federation, 119021.
Abstract
AIM: to assess macular blood flow in primary open-angle glaucoma (POAG) patients using optical coherence tomography angiography (OCT-A). MATERIAL AND METHODS: The study included 65 POAG patients and 22 age-matched healthy volunteers. Using OCT-A, blood flow parameters (Flow Area, Flow Index, and Vessel Density) were assessed in the para- and perifovea (0.6-2.5 mm and 2.5-5.5 mm, respectively) at the level of both superficial and deep vascular pexuses. Statistical analysis was performed with SPSS version 21 and MASS library of the R language. RESULTS: All the studied parameters were decreased in glaucoma patients as compared to healthy participants: Index superficial parafovea was 0.03±0.01 and 0.04±0.01 (p<0.001), respectively; Index superficial perifovea - 0.02±0.01 and 0.04±0.01 (p<0.001), respectively; Flow superficial parafovea area - 1.57±0.85 mm2 and 2.53±0.53 mm2 (p<0.001), respectively; Index deep parafovea - 0.02±0.02 and 0.03±0.01 (p<0.001), respectively; Index deep perifovea - 0.01 ±0.01 and 0,03±0.01 (p<0.001), respectively; and Flow deep parafovea area 1.02±0.9 mm2 and 1.97±0.82 mm2 (p<0.001), respectively. The differences were statistically significant between glaucoma patients and the controls, but not between glaucoma patients at different disease stages. CONCLUSION: Decreased OCT-A parameters in non-advanced glaucoma indicate an early reduction of blood supply to the macula and explain the involvement of the latter in the pathological process in POAG.
AIM: to assess macular blood flow in primary open-angle glaucoma (POAG) patients using optical coherence tomography angiography (OCT-A). MATERIAL AND METHODS: The study included 65 POAG patients and 22 age-matched healthy volunteers. Using OCT-A, blood flow parameters (Flow Area, Flow Index, and Vessel Density) were assessed in the para- and perifovea (0.6-2.5 mm and 2.5-5.5 mm, respectively) at the level of both superficial and deep vascular pexuses. Statistical analysis was performed with SPSS version 21 and MASS library of the R language. RESULTS: All the studied parameters were decreased in glaucomapatients as compared to healthy participants: Index superficial parafovea was 0.03±0.01 and 0.04±0.01 (p<0.001), respectively; Index superficial perifovea - 0.02±0.01 and 0.04±0.01 (p<0.001), respectively; Flow superficial parafovea area - 1.57±0.85 mm2 and 2.53±0.53 mm2 (p<0.001), respectively; Index deep parafovea - 0.02±0.02 and 0.03±0.01 (p<0.001), respectively; Index deep perifovea - 0.01 ±0.01 and 0,03±0.01 (p<0.001), respectively; and Flow deep parafovea area 1.02±0.9 mm2 and 1.97±0.82 mm2 (p<0.001), respectively. The differences were statistically significant between glaucomapatients and the controls, but not between glaucomapatients at different disease stages. CONCLUSION: Decreased OCT-A parameters in non-advanced glaucoma indicate an early reduction of blood supply to the macula and explain the involvement of the latter in the pathological process in POAG.
Authors: Huiyuan Hou; Sasan Moghimi; James A Proudfoot; Elham Ghahari; Rafaella C Penteado; Christopher Bowd; Diya Yang; Robert N Weinreb Journal: Ophthalmology Date: 2020-01-13 Impact factor: 12.079
Authors: Nevin W El-Nimri; Patricia Isabel C Manalastas; Linda M Zangwill; James A Proudfoot; Christopher Bowd; Huiyuan Hou; Sasan Moghimi; Rafaella C Penteado; Jasmin Rezapour; Eren Ekici; Takuhei Shoji; Elham Ghahari; Adeleh Yarmohammadi; Robert N Weinreb Journal: J Glaucoma Date: 2021-06-01 Impact factor: 2.290