| Literature DB >> 2852361 |
T Sata1, J Linden, L W Liu, E Kubota, S I Said.
Abstract
We have investigated VIP-induced relaxation and cyclic AMP accumulation in rat thoracic aorta strips, and the importance of endothelium to both actions. The relaxation was greatly attenuated by removal of endothelium, but was unaltered by cyclo-oxygenase or lipoxygenase inhibitors. Similarly, cyclic AMP formation was nearly abolished with loss of endothelium, but was largely unaffected by inhibitors of arachidonate pathways, cytochrome P450 or guanylate cyclase. VIP may stimulate the release of a diffusible factor from endothelium (an EDRF), which activates adenylate cyclase and relaxes aortic smooth muscle.Entities:
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Year: 1988 PMID： 2852361 DOI： 10.1016/0196-9781(88)90133-7
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750