Literature DB >> 2852319

Cation interactions with putative NMDA receptor-gated channels labeled by [3H]MK-801 in rat cerebral cortex.

D A Greenberg1, S S Marks.   

Abstract

Polyvalent cations that block excitatory responses to N-methyl-D-aspartate inhibited the binding of [3H]MK-801 to putative N-methyl-D-aspartate receptor-gated channels in brain membranes. The order of potency was Zn2+ greater than La3+ = Cd2+ greater than Mn2+ greater than Co2+ greater than Ni2+ = Mg2+. These findings support the existence of interacting sites on the N-methyl-D-aspartate channel for ionic and organic antagonists, and provide a molecular mechanism for the modulation of excitatory neurotransmission and excitotoxicity by endogenous polyvalent cations.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 2852319     DOI： 10.1016/0304-3940(88)90663-5

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  3 in total

Review 1.  A review of the in vitro and in vivo neurochemical characterization of the NMDA/PCP/glycine/ion channel receptor macrocomplex.

Authors:  P L Wood; T S Rao; S Iyengar; T Lanthorn; J Monahan; A Cordi; E Sun; M Vazquez; N Gray; P Contreras
Journal:  Neurochem Res       Date:  1990-02       Impact factor: 3.996

2.  Lanthanum actions on excitatory amino acid-gated currents and voltage-gated calcium currents in rat dorsal horn neurons.

Authors:  D B Reichling; A B MacDermott
Journal:  J Physiol       Date:  1991-09       Impact factor: 5.182

3.  Sub-synaptic localization of Cav3.1 T-type calcium channels in the thalamus of normal and parkinsonian monkeys.

Authors:  Erdong Chen; Jean-Francois Paré; Thomas Wichmann; Yoland Smith
Journal:  Brain Struct Funct       Date:  2016-06-02       Impact factor: 3.270
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.