Literature DB >> 28522034

Alpha-Synuclein mRNA Is Not Increased in Sporadic PD and Alpha-Synuclein Accumulation Does Not Block GDNF Signaling in Parkinson's Disease and Disease Models.

Xiaomin Su1, D Luke Fischer2, Xin Li3, Krystof Bankiewicz4, Caryl E Sortwell2, Howard J Federoff5.   

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Year:  2017        PMID： 28522034      PMCID： PMC5628770          DOI： 10.1016/j.ymthe.2017.04.018

Source DB:  PubMed          Journal:  Mol Ther        ISSN： 1525-0016            Impact factor:   11.454


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  18 in total

1.  α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study.

Authors:  Brit Mollenhauer; Joseph J Locascio; Walter Schulz-Schaeffer; Friederike Sixel-Döring; Claudia Trenkwalder; Michael G Schlossmacher
Journal:  Lancet Neurol       Date:  2011-03       Impact factor: 44.182

2.  GDNF fails to exert neuroprotection in a rat α-synuclein model of Parkinson's disease.

Authors:  Mickael Decressac; Ayse Ulusoy; Bengt Mattsson; Biljana Georgievska; Marina Romero-Ramos; Deniz Kirik; Anders Björklund
Journal:  Brain       Date:  2011-06-28       Impact factor: 13.501

3.  GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.

Authors:  Piotr Hadaczek; Gusheng Wu; Nitasha Sharma; Agnieszka Ciesielska; Krystof Bankiewicz; Amy L Davidow; Zi-Hua Lu; John Forsayeth; Robert W Ledeen
Journal:  Exp Neurol       Date:  2014-10-23       Impact factor: 5.330

4.  Alpha-synuclein expression in substantia nigra and cortex in Parkinson's disease.

Authors:  M Neystat; T Lynch; S Przedborski; N Kholodilov; M Rzhetskaya; R E Burke
Journal:  Mov Disord       Date:  1999-05       Impact factor: 10.338

5.  Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system.

Authors:  D Kirik; C Rosenblad; A Bjorklund; R J Mandel
Journal:  J Neurosci       Date:  2000-06-15       Impact factor: 6.167

6.  Regeneration of the MPTP-lesioned dopaminergic system after convection-enhanced delivery of AAV2-GDNF.

Authors:  Adrian P Kells; Jamie Eberling; Xiaomin Su; Philip Pivirotto; John Bringas; Piotr Hadaczek; Wade C Narrow; William J Bowers; Howard J Federoff; John Forsayeth; Krystof S Bankiewicz
Journal:  J Neurosci       Date:  2010-07-14       Impact factor: 6.167

7.  α-Synuclein-induced down-regulation of Nurr1 disrupts GDNF signaling in nigral dopamine neurons.

Authors:  Mickael Decressac; Banafsheh Kadkhodaei; Bengt Mattsson; Ariadna Laguna; Thomas Perlmann; Anders Björklund
Journal:  Sci Transl Med       Date:  2012-12-05       Impact factor: 17.956

8.  Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time- and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system.

Authors:  Biljana Georgievska; Deniz Kirik; Anders Björklund
Journal:  J Neurosci       Date:  2004-07-21       Impact factor: 6.167

9.  Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal system.

Authors:  Sara E Gombash; Fredric P Manfredsson; Christopher J Kemp; Nathan C Kuhn; Sheila M Fleming; Ann E Egan; Laura M Grant; Michelle R Ciucci; Jeffrey P MacKeigan; Caryl E Sortwell
Journal:  PLoS One       Date:  2013-11-27       Impact factor: 3.240

10.  Distinct pattern of enteric phospho-alpha-synuclein aggregates and gene expression profiles in patients with Parkinson's disease.

Authors:  Martina Barrenschee; Dimitri Zorenkov; Martina Böttner; Christina Lange; François Cossais; Amelie Bernadette Scharf; Günther Deuschl; Susanne A Schneider; Mark Ellrichmann; Annette Fritscher-Ravens; Thilo Wedel
Journal:  Acta Neuropathol Commun       Date:  2017-01-05       Impact factor: 7.801
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  21 in total

1.  α-Synuclein (αSyn) Preformed Fibrils Induce Endogenous αSyn Aggregation, Compromise Synaptic Activity and Enhance Synapse Loss in Cultured Excitatory Hippocampal Neurons.

Authors:  Qihui Wu; Hajime Takano; Dawn M Riddle; John Q Trojanowski; Douglas A Coulter; Virginia M-Y Lee
Journal:  J Neurosci       Date:  2019-04-29       Impact factor: 6.167

2.  Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils.

Authors:  Joseph R Patterson; Megan F Duffy; Christopher J Kemp; Jacob W Howe; Timothy J Collier; Anna C Stoll; Kathryn M Miller; Pooja Patel; Nathan Levine; Darren J Moore; Kelvin C Luk; Sheila M Fleming; Nicholas M Kanaan; Katrina L Paumier; Omar M A El-Agnaf; Caryl E Sortwell
Journal:  Neurobiol Dis       Date:  2019-07-02       Impact factor: 5.996

Review 3.  Parkinson's disease gene therapy: Will focused ultrasound and nanovectors be the next frontier?

Authors:  Richard J Price; Delaney G Fisher; Jung Soo Suk; Justin Hanes; Han Seok Ko; Jeffrey H Kordower
Journal:  Mov Disord       Date:  2019-03-25       Impact factor: 10.338

4.  Neuronal activity modulates alpha-synuclein aggregation and spreading in organotypic brain slice cultures and in vivo.

Authors:  Qihui Wu; Muhammad A Shaikh; Emily S Meymand; Bin Zhang; Kelvin C Luk; John Q Trojanowski; Virginia M-Y Lee
Journal:  Acta Neuropathol       Date:  2020-10-06       Impact factor: 17.088

5.  Subthalamic Nucleus Deep Brain Stimulation Does Not Modify the Functional Deficits or Axonopathy Induced by Nigrostriatal α-Synuclein Overexpression.

Authors:  D Luke Fischer; Fredric P Manfredsson; Christopher J Kemp; Allyson Cole-Strauss; Jack W Lipton; Megan F Duffy; Nicole K Polinski; Kathy Steece-Collier; Timothy J Collier; Sara E Gombash; Daniel J Buhlinger; Caryl E Sortwell
Journal:  Sci Rep       Date:  2017-11-27       Impact factor: 4.379

6.  Quality Over Quantity: Advantages of Using Alpha-Synuclein Preformed Fibril Triggered Synucleinopathy to Model Idiopathic Parkinson's Disease.

Authors:  Megan F Duffy; Timothy J Collier; Joseph R Patterson; Christopher J Kemp; D Luke Fischer; Anna C Stoll; Caryl E Sortwell
Journal:  Front Neurosci       Date:  2018-09-04       Impact factor: 4.677

7.  BDNF provides many routes toward STN DBS-mediated disease modification.

Authors:  D Luke Fischer; Caryl E Sortwell
Journal:  Mov Disord       Date:  2018-11-15       Impact factor: 10.338

8.  Randomized trial of intermittent intraputamenal glial cell line-derived neurotrophic factor in Parkinson's disease.

Authors:  Alan Whone; Matthias Luz; Mihaela Boca; Max Woolley; Lucy Mooney; Sonali Dharia; Jack Broadfoot; David Cronin; Christian Schroers; Neil U Barua; Lara Longpre; C Lynn Barclay; Chris Boiko; Greg A Johnson; H Christian Fibiger; Rob Harrison; Owen Lewis; Gemma Pritchard; Mike Howell; Charlie Irving; David Johnson; Suk Kinch; Christopher Marshall; Andrew D Lawrence; Stephan Blinder; Vesna Sossi; A Jon Stoessl; Paul Skinner; Erich Mohr; Steven S Gill
Journal:  Brain       Date:  2019-03-01       Impact factor: 13.501

9.  Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration.

Authors:  Megan F Duffy; Timothy J Collier; Joseph R Patterson; Christopher J Kemp; Kelvin C Luk; Malú G Tansey; Katrina L Paumier; Nicholas M Kanaan; D Luke Fischer; Nicole K Polinski; Olivia L Barth; Jacob W Howe; Nishant N Vaikath; Nour K Majbour; Omar M A El-Agnaf; Caryl E Sortwell
Journal:  J Neuroinflammation       Date:  2018-05-01       Impact factor: 8.322

Review 10.  Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's Disease.

Authors:  Paulina Troncoso-Escudero; Alejandra Parra; Melissa Nassif; Rene L Vidal
Journal:  Front Neurol       Date:  2018-10-15       Impact factor: 4.003
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