Literature DB >> 28521700

Glioblastoma Multiforme, Diagnosis and Treatment; Recent Literature Review.

Ron Batash1, Noam Asna2, Pamela Schaffer3, Nicole Francis4, Moshe Schaffer2.   

Abstract

BACKGROUND: Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor, with an incidence of 3.19 cases per 100,000 person years and remarkably poor prognosis showing a 5-year survival rate of 4-5%, and only a 26-33% survival rate at 2 years in clinical trials.
OBJECTIVE: In this paper, we review the different types of treatment modalities based on the relevant databases. Methods of diagnosis will be described briefly.
METHOD: Systemic compilation of the relevant literature. RESULTS &
CONCLUSION: Today's treatments cannot cure GBM patients but only extend their overall survival. The use of chemoradiation, immunotherapy, and radio sensitizers as an adjuvant therapy cannot reduce the high rates of recurrence within a few months after treatment. Radiotherapy will remain the backbone of the treatment but new treatment modalities must be developed. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities:  

Keywords:  Biologic agent; chemotherapy; glioblastoma multiforme; immunotherapy; radiation therapy; vaccination.

Mesh：

Substances：

Year:  2017        PMID： 28521700     DOI： 10.2174/0929867324666170516123206

Source DB:  PubMed          Journal:  Curr Med Chem        ISSN： 0929-8673            Impact factor:   4.530


  119 in total

1.  SQSTM1/p62 is involved in docosahexaenoic acid-induced cellular autophagy in glioblastoma cell lines.

Authors:  Xuefeng Tan; Linqing Zou; Jianbing Qin; Donglin Xia; Youlang Zhou; Guohua Jin; Zhuang Jiang; Haoming Li
Journal:  In Vitro Cell Dev Biol Anim       Date:  2019-08-19       Impact factor: 2.416

2.  The sialoglycan-Siglec-E checkpoint axis in dexamethasone-induced immune subversion in glioma-microglia transwell co-culture system.

Authors:  Przemyslaw Wielgat; Robert Czarnomysy; Emil Trofimiuk; Halina Car
Journal:  Immunol Res       Date:  2019-10       Impact factor: 2.829

Review 3.  Novel therapies hijack the blood-brain barrier to eradicate glioblastoma cancer stem cells.

Authors:  Raghupathy Vengoji; Moorthy P Ponnusamy; Satyanarayana Rachagani; Sidharth Mahapatra; Surinder K Batra; Nicole Shonka; Muzafar A Macha
Journal:  Carcinogenesis       Date:  2019-03-12       Impact factor: 4.944

4.  Circular RNA hsa_circ_0008344 regulates glioblastoma cell proliferation, migration, invasion, and apoptosis.

Authors:  Jinxu Zhou; Hongxiang Wang; Junsheng Chu; Qilin Huang; Guangxu Li; Yong Yan; Tao Xu; Juxiang Chen; Yuhai Wang
Journal:  J Clin Lab Anal       Date:  2018-04-24       Impact factor: 2.352

5.  Development of Pyrazolo[3,4-d]pyrimidine Kinase Inhibitors as Potential Clinical Candidates for Glioblastoma Multiforme.

Authors:  Chiara Greco; Vincenzo Taresco; Amanda K Pearce; Catherine E Vasey; Stuart Smith; Ruman Rahman; Cameron Alexander; Robert J Cavanagh; Francesca Musumeci; Silvia Schenone
Journal:  ACS Med Chem Lett       Date:  2020-02-13       Impact factor: 4.345

6.  Disseminated cryptococcal infection in a patient with glioblastoma multiforme on treatment with lomustine and bevacizumab.

Authors:  Adrienne M Gonzales; Tauqeer Yousuf
Journal:  Proc (Bayl Univ Med Cent)       Date:  2021-01-11

7.  Phenotypic Screening of Chemical Libraries Enriched by Molecular Docking to Multiple Targets Selected from Glioblastoma Genomic Data.

Authors:  David Xu; Donghui Zhou; Khuchtumur Bum-Erdene; Barbara J Bailey; Kamakshi Sishtla; Sheng Liu; Jun Wan; Uma K Aryal; Jonathan A Lee; Clark D Wells; Melissa L Fishel; Timothy W Corson; Karen E Pollok; Samy O Meroueh
Journal:  ACS Chem Biol       Date:  2020-05-21       Impact factor: 5.100

8.  miR-484/MAP2/c-Myc-positive regulatory loop in glioma promotes tumor-initiating properties through ERK1/2 signaling.

Authors:  Renhui Yi; Jiugeng Feng; Shaochun Yang; Xiaoyu Huang; Yuanyuan Liao; Zheng Hu; Muyun Luo
Journal:  J Mol Histol       Date:  2018-02-26       Impact factor: 2.611

9.  A Novel In Vitro Device to Deliver Induced Electromagnetic Fields to Cell and Tissue Cultures.

Authors:  Rea Ravin; Teddy X Cai; Randall H Pursley; Marcial Garmendia-Cedillos; Tom Pohida; Raisa Z Freidlin; Herui Wang; Zhengping Zhuang; Amber J Giles; Nathan H Williamson; Mark R Gilbert; Peter J Basser
Journal:  Biophys J       Date:  2020-11-13       Impact factor: 4.033

10.  Quantitative Characterization of Tumor Proximity to Stem Cell Niches: Implications on Recurrence and Survival in GBM Patients.

Authors:  Yi Lao; Victoria Yu; Anthony Pham; Theodore Wang; Jing Cui; Audrey Gallogly; Eric Chang; Zhaoyang Fan; Tania Kaprealian; Wensha Yang; Ke Sheng
Journal:  Int J Radiat Oncol Biol Phys       Date:  2021-02-16       Impact factor: 7.038
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