Kevin Messacar1, Christine C Robinson2, Kristin Pretty2, Ji Yuan2, Samuel R Dominguez3. 1. Children's Hospital Colorado, Aurora, CO, USA; University of Colorado Denver, Aurora, CO, USA. 2. Children's Hospital Colorado, Aurora, CO, USA. 3. Children's Hospital Colorado, Aurora, CO, USA; University of Colorado Denver, Aurora, CO, USA. Electronic address: samuel.dominguez@ucdenver.edu.
Abstract
BACKGROUND: The largest, most widespread outbreak of enterovirus D68 respiratory disease occurred from August to December of 2014 in the United States with 1153 confirmed infections in 49 states. The epidemiology of enterovirus D68 following the 2014 outbreak is unknown. OBJECTIVES: This study seeks to describe the epidemiology of enterovirus D68 circulation amongst Colorado children from 2014 to 2016. STUDY DESIGN: This is a prospective observational surveillance study of enterovirus D68 infection amongst children tested for respiratory pathogens from July-October 2014-2016 at Children's Hospital Colorado (CHCO), a quaternary care children's hospital in Aurora, CO. RESULTS: Amongst rhinovirus/enterovirus positive respiratory specimens from intensive care unit patients, ninety-eight of 314 (31.2%) in 2014, none of 307 (0%) specimens in 2015, and 19 of 240 (7.9%) specimens in 2016 were identified as enterovirus D68. Amongst respiratory specimens from all patients during the prospective active surveillance period, none of 1469 (0%) in 2015 and 46 of 1403 (3.3%) were positive for enterovirus D68. CONCLUSIONS: Surveillance for enterovirus D68 amongst respiratory specimens at a quaternary care children's hospital revealed a seasonal pattern of circulation in the late summer to early fall of 2014 and 2016. Continued surveillance of respiratory specimens is necessary to define the circulation pattern and understand the epidemiology of this emerging pathogen.
BACKGROUND: The largest, most widespread outbreak of enterovirus D68respiratory disease occurred from August to December of 2014 in the United States with 1153 confirmed infections in 49 states. The epidemiology of enterovirus D68 following the 2014 outbreak is unknown. OBJECTIVES: This study seeks to describe the epidemiology of enterovirus D68 circulation amongst Colorado children from 2014 to 2016. STUDY DESIGN: This is a prospective observational surveillance study of enterovirus D68 infection amongst children tested for respiratory pathogens from July-October 2014-2016 at Children's Hospital Colorado (CHCO), a quaternary care children's hospital in Aurora, CO. RESULTS: Amongst rhinovirus/enterovirus positive respiratory specimens from intensive care unit patients, ninety-eight of 314 (31.2%) in 2014, none of 307 (0%) specimens in 2015, and 19 of 240 (7.9%) specimens in 2016 were identified as enterovirus D68. Amongst respiratory specimens from all patients during the prospective active surveillance period, none of 1469 (0%) in 2015 and 46 of 1403 (3.3%) were positive for enterovirus D68. CONCLUSIONS: Surveillance for enterovirus D68 amongst respiratory specimens at a quaternary care children's hospital revealed a seasonal pattern of circulation in the late summer to early fall of 2014 and 2016. Continued surveillance of respiratory specimens is necessary to define the circulation pattern and understand the epidemiology of this emerging pathogen.
Authors: Kevin Messacar; Stephen M M Hawkins; Joyce Baker; Kelly Pearce; Suhong Tong; Samuel R Dominguez; Sarah Parker Journal: JAMA Pediatr Date: 2016-03 Impact factor: 16.193
Authors: James J Sejvar; Adriana S Lopez; Margaret M Cortese; Eyal Leshem; Daniel M Pastula; Lisa Miller; Carol Glaser; Anita Kambhampati; Kayoko Shioda; Negar Aliabadi; Marc Fischer; Nicole Gregoricus; Robert Lanciotti; W Allan Nix; Senthilkumar K Sakthivel; D Scott Schmid; Jane F Seward; Suxiang Tong; M Steven Oberste; Mark Pallansch; Daniel Feikin Journal: Clin Infect Dis Date: 2016-06-17 Impact factor: 9.079
Authors: Mark A Poritz; Anne J Blaschke; Carrie L Byington; Lindsay Meyers; Kody Nilsson; David E Jones; Stephanie A Thatcher; Thomas Robbins; Beth Lingenfelter; Elizabeth Amiott; Amy Herbener; Judy Daly; Steven F Dobrowolski; David H-F Teng; Kirk M Ririe Journal: PLoS One Date: 2011-10-19 Impact factor: 3.240
Authors: Todd N Wylie; Kristine M Wylie; Richard S Buller; Maria Cannella; Gregory A Storch Journal: J Clin Microbiol Date: 2015-06-10 Impact factor: 5.948
Authors: Claire M Midgley; John T Watson; W Allan Nix; Aaron T Curns; Shannon L Rogers; Betty A Brown; Craig Conover; Samuel R Dominguez; Daniel R Feikin; Samantha Gray; Ferdaus Hassan; Stacey Hoferka; Mary Anne Jackson; Daniel Johnson; Eyal Leshem; Lisa Miller; Janell Bezdek Nichols; Ann-Christine Nyquist; Emily Obringer; Ajanta Patel; Megan Patel; Brian Rha; Eileen Schneider; Jennifer E Schuster; Rangaraj Selvarangan; Jane F Seward; George Turabelidze; M Steven Oberste; Mark A Pallansch; Susan I Gerber Journal: Lancet Respir Med Date: 2015-10-05 Impact factor: 30.700
Authors: Negar Aliabadi; Kevin Messacar; Daniel M Pastula; Christine C Robinson; Eyal Leshem; James J Sejvar; W Allan Nix; M Steven Oberste; Daniel R Feikin; Samuel R Dominguez Journal: Emerg Infect Dis Date: 2016-08 Impact factor: 6.883
Authors: Marjolein Knoester; Elisabeth H Schölvinck; Randy Poelman; Sylvia Smit; Clementien L Vermont; Hubert G M Niesters; Coretta C Van Leer-Buter Journal: Emerg Infect Dis Date: 2017-01-15 Impact factor: 6.883
Authors: Terry Fei Fan Ng; Anna Montmayeur; Christina Castro; Marshall Cone; Joey Stringer; Daryl M Lamson; Shannon L Rogers; Shur-Wern Wang Chern; Laura Magaña; Rachel Marine; Heather Rubino; Daniel Serinaldi; Kirsten St George; W Allan Nix Journal: Genome Announc Date: 2016-12-08
Authors: Victoria L Gilrane; Jian Zhuge; Weihua Huang; Sheila M Nolan; Abhay Dhand; Changhong Yin; Christian Salib; Faariah Shakil; Helen Engel; John T Fallon; Guiqing Wang Journal: J Clin Microbiol Date: 2020-08-24 Impact factor: 5.948
Authors: Kevin Messacar; Edwin J Asturias; Alison M Hixon; Coretta Van Leer-Buter; Hubert G M Niesters; Kenneth L Tyler; Mark J Abzug; Samuel R Dominguez Journal: Lancet Infect Dis Date: 2018-02-23 Impact factor: 25.071
Authors: Olwen C Murphy; Kevin Messacar; Leslie Benson; Riley Bove; Jessica L Carpenter; Thomas Crawford; Janet Dean; Roberta DeBiasi; Jay Desai; Matthew J Elrick; Raquel Farias-Moeller; Grace Y Gombolay; Benjamin Greenberg; Matthew Harmelink; Sue Hong; Sarah E Hopkins; Joyce Oleszek; Catherine Otten; Cristina L Sadowsky; Teri L Schreiner; Kiran T Thakur; Keith Van Haren; Carolina M Carballo; Pin Fee Chong; Amary Fall; Vykuntaraju K Gowda; Jelte Helfferich; Ryutaro Kira; Ming Lim; Eduardo L Lopez; Elizabeth M Wells; E Ann Yeh; Carlos A Pardo Journal: Lancet Date: 2020-12-23 Impact factor: 79.321
Authors: Nguyen Thi Thuy Chinh B'Krong; Ngo Ngoc Quang Minh; Phan Tu Qui; Tran Thi Hong Chau; Ho Dang Trung Nghia; Lien Anh Ha Do; Nguyen Ngoc Nhung; Nguyen Van Vinh Chau; Guy Thwaites; Le Van Tan; H Rogier van Doorn; Tran Tan Thanh Journal: Virol J Date: 2018-04-12 Impact factor: 4.099