Literature DB >> 2851930

RO 15-4513 and its interaction with ethanol.

R G Lister1, D J Nutt.   

Abstract

It has recently been claimed that RO 15-4513 selectively opposes some of the behavioral actions of ethanol. Our studies on the intrinsic effects of this compound have shown it to be proconvulsant and to reduce exploratory behavior in mice. In these respects RO 15-4513 resembles a benzodiazepine receptor partial inverse agonist. Such intrinsic actions may well explain its alcohol-antagonizing properties, and argue against its potential in humans. In addition to partially reversing the effects of ethanol, RO 15-4513 also partially reverses the behavioral effect of a barbiturate and completely reverses the effects of a benzodiazepine.

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Year:  1988        PMID： 2851930     DOI： 10.1300/J251v07n03_19

Source DB:  PubMed          Journal:  Adv Alcohol Subst Abuse        ISSN： 0270-3106


  5 in total

1.  Behavioral pharmacogenetic analysis on the role of the α4 GABA(A) receptor subunit in the ethanol-mediated impairment of hippocampus-dependent contextual learning.

Authors:  Jesse D Cushman; Melissa D Moore; Nate S Jacobs; Richard W Olsen; Michael S Fanselow
Journal:  Alcohol Clin Exp Res       Date:  2011-09-21       Impact factor: 3.455

2.  Ethanol self-administration in freely feeding and drinking rats: effects of Ro15-4513 alone, and in combination with Ro15-1788 (flumazenil).

Authors:  H L June; R W Hughes; H L Spurlock; M J Lewis
Journal:  Psychopharmacology (Berl)       Date:  1994-07       Impact factor: 4.530

Review 3.  Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABAA receptors as an opportunity for drug development?

Authors:  M Wallner; R W Olsen
Journal:  Br J Pharmacol       Date:  2008-02-18       Impact factor: 8.739

Review 4.  The dynamics of GABA signaling: Revelations from the circadian pacemaker in the suprachiasmatic nucleus.

Authors:  H Elliott Albers; James C Walton; Karen L Gamble; John K McNeill; Daniel L Hummer
Journal:  Front Neuroendocrinol       Date:  2016-11-25       Impact factor: 8.606

5.  α4-Containing GABA(A) Receptors are Required for Antagonism of Ethanol-Induced Motor Incoordination and Hypnosis by the Imidazobenzodiazepine Ro15-4513.

Authors:  Sangeetha V Iyer; Rodrigo A Benavides; Dev Chandra; James M Cook; Sundari Rallapalli; Harry L June; Gregg E Homanics
Journal:  Front Pharmacol       Date:  2011-04-04       Impact factor: 5.810
  5 in total

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