Literature DB >> 28517007

Generation of a cell-permeable cycloheptapeptidyl inhibitor against the peptidyl-prolyl isomerase Pin1.

Walaa Bedewy1, Hui Liao, Nageh A Abou-Taleb, Sherif F Hammad, Tamer Nasr, Dehua Pei.   

Abstract

Cyclic peptides are capable of binding and modulating challenging drug targets including protein-protein interactions. However, their lack of membrane permeability prevents their application against intracellular targets. In this study, we show that it is possible to design a cell-permeable and biologically active cycloheptapeptide inhibitor against the intracellular enzyme peptidyl-prolyl isomerase Pin1 by integrating cell-penetrating and target-binding sequences.

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Year:  2017        PMID： 28517007      PMCID： PMC5520971          DOI： 10.1039/c7ob00430c

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  27 in total

1.  Discovery and characterization of a nonphosphorylated cyclic peptide inhibitor of the peptidylprolyl isomerase, Pin1.

Authors:  Kelly E Duncan; Brian R Dempsey; Lauren E Killip; Jarrett Adams; Melanie L Bailey; Gilles A Lajoie; David W Litchfield; Christopher J Brandl; Gary S Shaw; Brian H Shilton
Journal:  J Med Chem       Date:  2011-05-05       Impact factor: 7.446

2.  Discovery and Mechanism of Highly Efficient Cyclic Cell-Penetrating Peptides.

Authors:  Ziqing Qian; Agnieszka Martyna; Ryan L Hard; Jiang Wang; George Appiah-Kubi; Christopher Coss; Mitch A Phelps; Jeremy S Rossman; Dehua Pei
Journal:  Biochemistry       Date:  2016-04-28       Impact factor: 3.162

Review 3.  Cell permeability beyond the rule of 5.

Authors:  Pär Matsson; Bradley C Doak; Björn Over; Jan Kihlberg
Journal:  Adv Drug Deliv Rev       Date:  2016-04-09       Impact factor: 15.470

4.  Phage display-directed discovery of LEDGF/p75 binding cyclic peptide inhibitors of HIV replication.

Authors:  Belete A Desimmie; Michael Humbert; Eveline Lescrinier; Jelle Hendrix; Sofie Vets; Rik Gijsbers; Ruth M Ruprecht; Ursula Dietrich; Zeger Debyser; Frauke Christ
Journal:  Mol Ther       Date:  2012-07-24       Impact factor: 11.454

5.  Pin1 inhibitors: Pitfalls, progress and cellular pharmacology.

Authors:  Jonathan D Moore; Andrew Potter
Journal:  Bioorg Med Chem Lett       Date:  2013-06-06       Impact factor: 2.823

6.  Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G(0) arrest.

Authors:  F Fujimori; K Takahashi; C Uchida; T Uchida
Journal:  Biochem Biophys Res Commun       Date:  1999-11-30       Impact factor: 3.575

7.  Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.

Authors:  Haibin Zhou; Liu Liu; Jing Huang; Denzil Bernard; Hacer Karatas; Alexandro Navarro; Ming Lei; Shaomeng Wang
Journal:  J Med Chem       Date:  2013-01-17       Impact factor: 7.446

8.  Going Out on a Limb: Delineating The Effects of β-Branching, N-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of Sanguinamide A Analogues.

Authors:  Andrew T Bockus; Joshua A Schwochert; Cameron R Pye; Chad E Townsend; Vong Sok; Maria A Bednarek; R Scott Lokey
Journal:  J Med Chem       Date:  2015-09-02       Impact factor: 7.446

9.  Efficient delivery of cyclic peptides into mammalian cells with short sequence motifs.

Authors:  Ziqing Qian; Tao Liu; Yu-Yu Liu; Roger Briesewitz; Amy M Barrios; Sissy M Jhiang; Dehua Pei
Journal:  ACS Chem Biol       Date:  2012-11-12       Impact factor: 5.100

10.  Chemical or genetic Pin1 inhibition exerts potent anticancer activity against hepatocellular carcinoma by blocking multiple cancer-driving pathways.

Authors:  Xin-Hua Liao; Arina Li Zhang; Min Zheng; Mei-Qing Li; Champ Peng Chen; Huijuan Xu; Qing-Song Chu; Dayun Yang; Wenxian Lu; Ting-Fen Tsai; Hekun Liu; Xiao Zhen Zhou; Kun Ping Lu
Journal:  Sci Rep       Date:  2017-03-06       Impact factor: 4.379
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  8 in total

1.  Designing Cell-Permeable Macrocyclic Peptides.

Authors:  George Appiah Kubi; Patrick G Dougherty; Dehua Pei
Journal:  Methods Mol Biol       Date:  2019

2.  Cell-Permeable Bicyclic Peptidyl Inhibitors against NEMO-IκB Kinase Interaction Directly from a Combinatorial Library.

Authors:  Curran A Rhodes; Patrick G Dougherty; Jahan K Cooper; Ziqing Qian; Steffen Lindert; Qi-En Wang; Dehua Pei
Journal:  J Am Chem Soc       Date:  2018-09-11       Impact factor: 15.419

3.  Understanding Cell Penetration of Cyclic Peptides.

Authors:  Patrick G Dougherty; Ashweta Sahni; Dehua Pei
Journal:  Chem Rev       Date:  2019-05-14       Impact factor: 60.622

Review 4.  Targeting intracellular protein-protein interactions with macrocyclic peptides.

Authors:  Marina Buyanova; Dehua Pei
Journal:  Trends Pharmacol Sci       Date:  2021-12-13       Impact factor: 14.819

5.  Hydrolysis, polarity, and conformational impact of C-terminal partially fluorinated ethyl esters in peptide models.

Authors:  Vladimir Kubyshkin; Nediljko Budisa
Journal:  Beilstein J Org Chem       Date:  2017-11-16       Impact factor: 2.883

Review 6.  Prolyl isomerase Pin1: a promoter of cancer and a target for therapy.

Authors:  Yang Chen; Ya-Ran Wu; Hong-Ying Yang; Xin-Zhe Li; Meng-Meng Jie; Chang-Jiang Hu; Yu-Yun Wu; Shi-Ming Yang; Ying-Bin Yang
Journal:  Cell Death Dis       Date:  2018-08-29       Impact factor: 8.469

7.  Design and Synthesis of Oligopeptidic Parvulin Inhibitors.

Authors:  Nicola Relitti; A Prasanth Saraswati; Gabriele Carullo; Alessandro Papa; Alessandra Monti; Rosaria Benedetti; Eugenia Passaro; Simone Brogi; Vincenzo Calderone; Stefania Butini; Sandra Gemma; Lucia Altucci; Giuseppe Campiani; Nunzianna Doti
Journal:  ChemMedChem       Date:  2022-04-26       Impact factor: 3.540

Review 8.  Targeting Pin1 for Modulation of Cell Motility and Cancer Therapy.

Authors:  Hsiang-Hao Chuang; Yen-Yi Zhen; Yu-Chen Tsai; Cheng-Hao Chuang; Ming-Shyan Huang; Michael Hsiao; Chih-Jen Yang
Journal:  Biomedicines       Date:  2021-03-31
  8 in total

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