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Literature DB >> 2851543

Tumour necrosis factors modulate the affinity state of the leukotriene B4 receptor on human neutrophils.

Abstract

Pre-incubation of human polymorphonuclear granulocytes with recombinant human tumour necrosis factors (TNF) revealed a time- and dose-dependent reduction of the expression of leukotriene B4-receptor sites. Analysis of the binding data by Scatchard plots showed a shift from a heterologous receptor population (indicating high- and low-affinity subsets) to a homologous population. From the results it is considered that TNF can influence host defence through the modulation of leukotriene B4 receptor affinity.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1988 PMID： 2851543 PMCID： PMC1385578

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

18 in total

1. A graphic method for the determination and presentation of binding parameters in a complex system.

Authors: H E Rosenthal
Journal: Anal Biochem Date: 1967-09 Impact factor: 3.365

2. An endotoxin-induced serum factor that causes necrosis of tumors.

Authors: E A Carswell; L J Old; R L Kassel; S Green; N Fiore; B Williamson
Journal: Proc Natl Acad Sci U S A Date: 1975-09 Impact factor: 11.205

Review 3. The pharmacology and pathophysiology of leukotriene B4.

Authors: M A Bray
Journal: Br Med Bull Date: 1983-07 Impact factor: 4.291

4. Human granulocyte-macrophage colony-stimulating factor is a neutrophil activator.

Authors: R H Weisbart; D W Golde; S C Clark; G G Wong; J C Gasson
Journal: Nature Date: 1985 Mar 28-Apr 3 Impact factor: 49.962

5. Arachidonic acid metabolites from polymorphonuclear leukocytes of healthy donors, severely burned patients and children with cystic fibrosis--routine monitoring by high-performance liquid chromatography.

Authors: J Knöller; W Schönfeld; M Köller; T Hensler; W König
Journal: J Chromatogr Date: 1988-06-03

10. Heterogeneity of human polymorphonuclear leukocyte receptors for leukotriene B4. Identification of a subset of high affinity receptors that transduce the chemotactic response.

Authors: D W Goldman; E J Goetzl
Journal: J Exp Med Date: 1984-04-01 Impact factor: 14.307

5 in total

5. Effects of adhesins from mannose-resistant Escherichia coli on mediator release from human lymphocytes, monocytes, and basophils and from polymorphonuclear granulocytes.

Authors: Y Ventur; J Scheffer; J Hacker; W Goebel; W König
Journal: Infect Immun Date: 1990-06 Impact factor: 3.441

5 in total

Tumour necrosis factors modulate the affinity state of the leukotriene B4 receptor on human neutrophils.

1. A graphic method for the determination and presentation of binding parameters in a complex system.

2. An endotoxin-induced serum factor that causes necrosis of tumors.

Review 3. The pharmacology and pathophysiology of leukotriene B4.

4. Human granulocyte-macrophage colony-stimulating factor is a neutrophil activator.

5. Arachidonic acid metabolites from polymorphonuclear leukocytes of healthy donors, severely burned patients and children with cystic fibrosis--routine monitoring by high-performance liquid chromatography.

6. Human tumor necrosis factor. Production, purification, and characterization.

7. Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors.

8. Arachidonic acid metabolites regulate interleukin-1 production.

9. Leukotrienes augment interleukin 1 production by human monocytes.

10. Heterogeneity of human polymorphonuclear leukocyte receptors for leukotriene B4. Identification of a subset of high affinity receptors that transduce the chemotactic response.

1. Studies on the uptake, binding and metabolism of leukotriene B4 by human neutrophils.

2. Effect of interferon-alpha on neutrophil functions.

3. Re-evaluation of the chemotactic activity of tumour necrosis factor for monocytes.

Review 4. Cytokines and eicosanoids in rheumatic diseases.

5. Effects of adhesins from mannose-resistant Escherichia coli on mediator release from human lymphocytes, monocytes, and basophils and from polymorphonuclear granulocytes.