Background: Dietary intake of phytonutrients present in fruits and vegetables, such as carotenoids, is associated with a lower risk of obesity and related traits, but the impact of genetic variation on these associations is poorly understood, especially in children.Objective: We estimated common genetic influences on serum carotenoid concentrations and obesity-related traits in Mexican American (MA) children.Design: Obesity-related data were obtained from 670 nondiabetic MA children, aged 6-17 y. Serum α- and β-carotenoid concentrations were measured in ∼570 (α-carotene in 565 and β-carotene in 572) of these children with the use of an ultraperformance liquid chromatography-photodiode array. We determined heritabilities for both carotenoids and examined their genetic relation with 10 obesity-related traits [body mass index (BMI), waist circumference (WC), high-density lipoprotein (HDL) cholesterol, triglycerides, fat mass (FM), systolic and diastolic blood pressure, fasting insulin and glucose, and homeostasis model assessment of insulin resistance] by using family data and a variance components approach. For these analyses, carotenoid values were inverse normalized, and all traits were adjusted for significant covariate effects of age and sex. Results: Carotenoid concentrations were highly heritable and significant [α-carotene: heritability (h2) = 0.81, P = 6.7 × 10-11; β-carotene: h2 = 0.90, P = 3.5 × 10-15]. After adjusting for multiple comparisons, we found significant (P ≤ 0.05) negative phenotypic correlations between carotenoid concentrations and the following traits: BMI, WC, FM, and triglycerides (range: α-carotene = -0.19 to -0.12; β-carotene = -0.24 to -0.13) and positive correlations with HDL cholesterol (α-carotene = 0.17; β-carotene = 0.24). However, when the phenotypic correlations were partitioned into genetic and environmental correlations, we found marginally significant (P = 0.051) genetic correlations only between β-carotene and BMI (-0.27), WC (-0.30), and HDL cholesterol (0.31) after accounting for multiple comparisons. None of the environmental correlations were significant.Conclusions: The findings from this study suggest that the serum carotenoid concentrations were under strong additive genetic influences based on variance components analyses, and that the common genetic factors may influence β-carotene and obesity and lipid traits in MA children.
Background: Dietary intake of phytonutrients present in fruits and vegetables, such as carotenoids, is associated with a lower risk of obesity and related traits, but the impact of genetic variation on these associations is poorly understood, especially in children.Objective: We estimated common genetic influences on serum carotenoid concentrations and obesity-related traits in Mexican American (MA) children.Design: Obesity-related data were obtained from 670 nondiabetic MA children, aged 6-17 y. Serum α- and β-carotenoid concentrations were measured in ∼570 (α-carotene in 565 and β-carotene in 572) of these children with the use of an ultraperformance liquid chromatography-photodiode array. We determined heritabilities for both carotenoids and examined their genetic relation with 10 obesity-related traits [body mass index (BMI), waist circumference (WC), high-density lipoprotein (HDL) cholesterol, triglycerides, fat mass (FM), systolic and diastolic blood pressure, fasting insulin and glucose, and homeostasis model assessment of insulin resistance] by using family data and a variance components approach. For these analyses, carotenoid values were inverse normalized, and all traits were adjusted for significant covariate effects of age and sex. Results:Carotenoid concentrations were highly heritable and significant [α-carotene: heritability (h2) = 0.81, P = 6.7 × 10-11; β-carotene: h2 = 0.90, P = 3.5 × 10-15]. After adjusting for multiple comparisons, we found significant (P ≤ 0.05) negative phenotypic correlations between carotenoid concentrations and the following traits: BMI, WC, FM, and triglycerides (range: α-carotene = -0.19 to -0.12; β-carotene = -0.24 to -0.13) and positive correlations with HDL cholesterol (α-carotene = 0.17; β-carotene = 0.24). However, when the phenotypic correlations were partitioned into genetic and environmental correlations, we found marginally significant (P = 0.051) genetic correlations only between β-carotene and BMI (-0.27), WC (-0.30), and HDL cholesterol (0.31) after accounting for multiple comparisons. None of the environmental correlations were significant.Conclusions: The findings from this study suggest that the serum carotenoid concentrations were under strong additive genetic influences based on variance components analyses, and that the common genetic factors may influence β-carotene and obesity and lipid traits in MA children.
Authors: M L Neuhouser; C L Rock; A L Eldridge; A R Kristal; R E Patterson; D A Cooper; D Neumark-Sztainer; L J Cheskin; M D Thornquist Journal: J Nutr Date: 2001-08 Impact factor: 4.798
Authors: Tracy L Burrows; Janet M Warren; Kim Colyvas; Manohar L Garg; Clare E Collins Journal: Obesity (Silver Spring) Date: 2008-11-06 Impact factor: 5.002
Authors: Srinivas Mummidi; Vidya S Farook; Lavanya Reddivari; Joselin Hernandez-Ruiz; Alvaro Diaz-Badillo; Sharon P Fowler; Roy G Resendez; Feroz Akhtar; Donna M Lehman; Christopher P Jenkinson; Rector Arya; Jane L Lynch; Jose A Canas; Ralph A DeFronzo; Daniel E Hale; John Blangero; Juan Carlos Lopez-Alvarenga; Ravindranath Duggirala; Jairam K P Vanamala Journal: Sci Rep Date: 2021-01-13 Impact factor: 4.379
Authors: María Marhuenda-Muñoz; Inés Domínguez-López; Klaus Langohr; Anna Tresserra-Rimbau; Miguel Ángel Martínez González; Jordi Salas-Salvadó; Dolores Corella; María Dolores Zomeño; J Alfredo Martínez; Angel M Alonso-Gómez; Julia Wärnberg; Jesús Vioque; Dora Romaguera; José López-Miranda; Ramón Estruch; Francisco J Tinahones; José Lapetra; Ll Serra-Majem; Aurora Bueno-Cavanillas; Josep A Tur; Vicente Martín-Sánchez; Xavier Pintó; Miguel Delgado-Rodríguez; Pilar Matía-Martín; Josep Vidal; Clotilde Vázquez; Lidia Daimiel; Emilio Ros; Estefanía Toledo; María Fernández de la Puente Cervera; Rocío Barragán; Montse Fitó; Lucas Tojal-Sierra; Enrique Gómez-Gracia; Juan Manuel Zazo; Marga Morey; Antonio García-Ríos; Rosa Casas; Ana M Gómez-Pérez; José Manuel Santos-Lozano; Zenaida Vázquez-Ruiz; Alessandro Atzeni; Eva M Asensio; M Mar Gili-Riu; Vanessa Bullon; Anai Moreno-Rodriguez; Oscar Lecea; Nancy Babio; Francesca Peñas Lopez; Guadalupe Gómez Melis; Rosa M Lamuela-Raventós Journal: Front Nutr Date: 2022-09-29
Authors: Amy R Bentley; Guanjie Chen; Ayo P Doumatey; Daniel Shriner; Karlijn A C Meeks; Mateus H Gouveia; Kenneth Ekoru; Jie Zhou; Adebowale Adeyemo; Charles N Rotimi Journal: Hum Mol Genet Date: 2021-11-01 Impact factor: 5.121