| Literature DB >> 28515019 |
Li-Jian Zhang1, Bin Chen1, Jun-Jie Zhang1, Jian Li1, Qingjing Yang1, Qi-Sheng Zhong2, Song Zhan2, Huwei Liu3, Chun Cai4.
Abstract
The biomarker identification of cancer is benefit for early detection and less invasion. Polyunsaturated fatty acid (PUFA) metabolite as inflammatory mediators can affect progression and treatment of cancer. In this work, the serum was collected from colorectal cancer patients and healthy volunteers, and then we tested the change of serum PUFA metabolites in both of them by ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). Of the 158 PUFA and their metabolites, we found that abnormal change of 2, 3-dinor-8-iso-PGF2α, 19-HETE and 12-keto-LTB4 from arachidonic acid were observed in colorectal cancer patients. Meanwhile, 9-HODE and 13-HODE from linoleic acid were significant lower in colorectal cancer patients. Our data suggested that some PUFA metabolites might be used as a potential biomarker of colorectal cancer, which might provide assistance in clinical diagnosis and treatment.Entities:
Keywords: Colorectal cancer; Lipidomic; Mass spectrometry; Ultra-high performance liquid chromatography
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Year: 2017 PMID： 28515019 DOI： 10.1016/j.plefa.2017.04.003
Source DB: PubMed Journal: Prostaglandins Leukot Essent Fatty Acids ISSN： 0952-3278 Impact factor: 4.006