| Literature DB >> 28514599 |
Lewis J Hutfles1,2, Heather M Wilkins2,3, Scott J Koppel2,4, Ian W Weidling2,4, J Eva Selfridge2,4, Eephie Tan5, John P Thyfault4,6, Chad Slawson5, Aron W Fenton5, Hao Zhu5,7, Russell H Swerdlow2,3,4,5.
Abstract
Ketogenic diets induce hepatocyte fatty acid oxidation and ketone body production. To further evaluate how ketogenic diets affect hepatocyte bioenergetic infrastructure, we analyzed livers from C57Bl/6J male mice maintained for 1 month on a ketogenic or standard chow diet. Compared with the standard diet, the ketogenic diet increased cytosolic and mitochondrial protein acetylation and also altered protein succinylation patterns. SIRT3 protein decreased while SIRT5 protein increased, and gluconeogenesis, oxidative phosphorylation, and mitochondrial biogenesis pathway proteins were variably and likely strategically altered. The pattern of changes observed can be used to inform a broader systems overview of how ketogenic diets affect liver bioenergetics.Entities:
Keywords: bioenergetics; bioénergétique; foie; hepatocyte; hépatocyte; ketogenic diet; liver; mitochondria; mitochondrie; régime cétogène
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Year: 2017 PMID： 28514599 PMCID： PMC5857360 DOI： 10.1139/apnm-2017-0068
Source DB: PubMed Journal: Appl Physiol Nutr Metab ISSN： 1715-5312 Impact factor: 2.665