Literature DB >> 28514281

Acute hyperinsulinemia effects on systemic markers of immune activation in HIV.

Timothy K O'Malley1, Tricia H Burdo, Jake A Robinson, Kathleen V Fitch, Steven K Grinspoon, Suman Srinivasa.   

Abstract

: The well treated HIV population remains at risk for insulin resistance and chronic immune activation. We tested the effects of acute hyperinsulinemia on inflammation in HIV. Twenty HIV-infected and 10 non-HIV-infected individuals well matched for BMI underwent oral glucose tolerance testing to stimulate insulin secretion and assess for changes in circulating soluble CD163, soluble CD14, and monocyte chemoattract protein 1. Soluble CD14 decreased significantly after stimulation of hyperinsulinemia and no significant changes in soluble CD163 or monocyte chemoattract protein 1 were demonstrated in HIV-infected and non-HIV-infected groups.

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Year:  2017        PMID： 28514281      PMCID： PMC5524206          DOI： 10.1097/QAD.0000000000001545

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.632


  13 in total

1.  Higher CD163 levels are associated with insulin resistance in hepatitis C virus-infected and HIV-infected adults.

Authors:  Michael Reid; Yifei Ma; Rebecca Scherzer; Jennifer C Price; Audrey L French; Michael W Plankey; Carl Grunfeld; Phyllis C Tien
Journal:  AIDS       Date:  2017-01-28       Impact factor: 4.177

2.  Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins.

Authors:  Carey N Lumeng; Stephanie M Deyoung; Alan R Saltiel
Journal:  Am J Physiol Endocrinol Metab       Date:  2006-08-22       Impact factor: 4.310

3.  Effect of glucose ingestion in plasma markers of inflammation and oxidative stress: analysis of 16 plasma markers from oral glucose tolerance test samples of normal and diabetic patients.

Authors:  Hyung Jin Choi; Soon Young Jeon; Won Kyung Hong; Seung Eun Jung; Hyun Ju Kang; Jun-Woo Kim; Jae-Pil Jeon; Bok-Ghee Han
Journal:  Diabetes Res Clin Pract       Date:  2013-02-11       Impact factor: 5.602

4.  Arterial inflammation in patients with HIV.

Authors:  Sharath Subramanian; Ahmed Tawakol; Tricia H Burdo; Suhny Abbara; Jeffrey Wei; Jayanthi Vijayakumar; Erin Corsini; Amr Abdelbaky; Markella V Zanni; Udo Hoffmann; Kenneth C Williams; Janet Lo; Steven K Grinspoon
Journal:  JAMA       Date:  2012-07-25       Impact factor: 56.272

5.  Soluble CD163 made by monocyte/macrophages is a novel marker of HIV activity in early and chronic infection prior to and after anti-retroviral therapy.

Authors:  Tricia H Burdo; Margaret R Lentz; Patrick Autissier; Anitha Krishnan; Elkan Halpern; Scott Letendre; Eric S Rosenberg; Ronald J Ellis; Kenneth C Williams
Journal:  J Infect Dis       Date:  2011-07-01       Impact factor: 5.226

6.  Noncalcified coronary atherosclerotic plaque and immune activation in HIV-infected women.

Authors:  Kathleen V Fitch; Suman Srinivasa; Suhny Abbara; Tricia H Burdo; Kenneth C Williams; Peace Eneh; Janet Lo; Steven K Grinspoon
Journal:  J Infect Dis       Date:  2013-09-16       Impact factor: 5.226

7.  Circulating levels of the shed scavenger receptor sCD163 and association with outcome of critically ill patients.

Authors:  Catherine Ingels; Holger J Møller; Troels K Hansen; Pieter J Wouters; Ilse Vanhorebeek; Greet Van den Berghe
Journal:  J Clin Immunol       Date:  2012-11-13       Impact factor: 8.317

8.  Monocyte chemoattractant protein 1 in obesity and insulin resistance.

Authors:  Peter Sartipy; David J Loskutoff
Journal:  Proc Natl Acad Sci U S A       Date:  2003-05-19       Impact factor: 11.205

9.  Inflammatory mediators in morbidly obese subjects: associations with glucose abnormalities and changes after oral glucose.

Authors:  Dag Hofsø; Thor Ueland; Helle Hager; Trond Jenssen; Jens Bollerslev; Kristin Godang; Pål Aukrust; Jo Røislien; Jøran Hjelmesaeth
Journal:  Eur J Endocrinol       Date:  2009-06-19       Impact factor: 6.664

10.  Monocytes expand with immune dysregulation and is associated with insulin resistance in older individuals with chronic HIV.

Authors:  Cecilia M Shikuma; Dominic C Chow; Louie Mar A Gangcuangco; Guangxiang Zhang; Sheila M Keating; Philip J Norris; Todd B Seto; Nisha Parikh; Kalpana J Kallianpur; Beau K Nakamoto; Lorna S Nagamine; Lishomwa C Ndhlovu; Jason D Barbour
Journal:  PLoS One       Date:  2014-02-27       Impact factor: 3.240
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  1 in total

Review 1.  Factors Associated With Insulin Resistance in Adults With HIV Receiving Contemporary Antiretroviral Therapy: a Brief Update.

Authors:  Todd Hulgan
Journal:  Curr HIV/AIDS Rep       Date:  2018-06       Impact factor: 5.071
  1 in total

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